摘要
1,4-二氢吡啶类化合物具有多种生物活性,在临床上受到广泛应用,普遍用于各类心脑血管疾病的治疗。以3-氰基吡啶和含不同取代基的溴化苄为原料在加热回流15h的条件下合成中间体盐;以硼氢化钾(KBH4)作为还原剂,在冰水浴搅拌的情况下,与中间体盐反应,合成了15个结构新颖的1,4-二氢吡啶衍生物(a^o),产率可达85%~90%,其结构经1H NMR、13C NMR和质谱进行表征。该方法具有成本低、环境友好、操作简单、产率高的特点。
1,4-dihydropyridine compounds have a variety of biological activities and are widely used in the treatment of various cardiovascular and cerebrovascular diseases.The intermediate salts were synthesized from 3-cyanopyridine and benzyl bromide containing different substituents under the condition of reflux for 15 hours.Potassium borohydride(KBH4)was used for the reduction of the intermediate salts in an ice-water bath,15 relatively novel 1,4-dihydrogen pyridine derivatives(a^o)were synthesized with the yield of 85%~90%.Their structures were characterized by 1H NMR,13C NMR and MS.The method has the characteristics of low cost,environmently friendly,easy operation and high yield.
作者
闫金花
张秀欣
杨宇鑫
钟启迪
Yan Jinhua;Zhang Xiuxin;Yang Yuxin;Zhong Qidi(College of Pharmacy,North China University of Science and Technology,Tangshan,063200)
出处
《化学通报》
CAS
CSCD
北大核心
2020年第8期735-740,共6页
Chemistry
基金
河北省教育厅青年基金项目(QN2019165)资助。
关键词
1
4-二氢吡啶
合成
硼氢化钾
3-氰基吡啶
1,4-Dihydropyridine
Synthesis
Potassium borohydride
3-Cyanopyridine
