摘要
目的:临床观察并证实肾衰饮对糖尿病肾病大鼠肾功能及β2微球蛋白(β2-MG)的影响作用。方法:采用腹腔注射链脲佐菌素,诱导大鼠糖尿病肾病(DN)模型,将大鼠随机分为肾衰饮治疗组(中药组)、西药治疗组(替米沙坦组)、模型组和空白对照组(正常组),各组相应药物剂量灌胃,给药8w后抽检各组大鼠空腹血糖、血脂、血肌酐、尿素和24h尿蛋白定量、尿β2微球蛋白水平等指标。结果:肾衰饮和替米沙坦对糖尿病肾病大鼠24h尿蛋白定量、血脂、血糖、尿素、血肌酐、尿β2微球蛋白水平等均有改善作用,两个治疗组大鼠尿蛋白定量和尿β2微球蛋白明显低于模型组(P<0.01),但中药治疗组要高于替米沙坦组(P<0.05)。结论:肾衰饮对糖尿病肾病大鼠具有治疗作用。
Objective:The effect of Shenshuai Drink on renal function andβ2-microglobulin(β2-MG)for diabetic nephropathy rats was observed and confirmed.Methods:Diabetic nephropathy(DN)model was induced by intraperitoneal injection of Streptozotocin.The rats were randomly divided into three groups:Shenshuai Drink treatment group(traditional Chinese medicine group),western medicine treatment group(Telmisartan group),model group and blank controlled group(normal group).The rats in each group were given the corresponding drug dose by gavage.After 8weeks of administration,the fasting blood glucose,blood lipid,blood creatinine,urea and 24-hour urine protein quantification,urineβ2-microglobulin were randomly examined and other indicators.Results:Shenshuai Drink and Telmisartan can improve 24-hour urine protein quantity,blood lipid,blood glucose,urea,serum creatinine and urineβ2-microglobulin level in diabetic nephropathy rats.The urinary protein andβ2-microglobulin in the two treatment groups were significantly lower than those in the model group(P<0.01),but higher in the traditional Chinese medicine treatment group than in the Telmisartan group(P<0.05).Conclusion:Shenshuai Drink has therapeutic effect on diabetic nephropathy rats.
作者
宫成军
马晓燕
GONG Chengjun;MA Xiaoyan(The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110032,China)
出处
《四川中医》
2020年第8期46-48,共3页
Journal of Sichuan of Traditional Chinese Medicine
基金
辽宁省自然基金指导计划(编号:2019-ZD-0439)。
