摘要
目的:观察酒毒内蕴型急性酒精中毒(AAI)患者应用醒脑静治疗对呼气酒精浓度水平的影响。方法:选取2016年7月~2019年7月我院收治的118例酒毒内蕴型AAI患者,并用随机数字表法将其随机分为对照组、观察组,每组各59例,其中对照组给予纳洛酮治疗,观察组在对照组的基础上联合给予醒脑静治疗;统计两组患者的中医证候治疗效果;比较两组患者治疗后的意识恢复时间、中毒症状消失时间以及肢体运动恢复时间;比较两组患者治疗前、后的血氧饱和度(SpO_2)、动脉血氧(CaO_2)和呼气酒精浓度(BrAC)水平;比较两组患者治疗前、后的超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)氧化应激相关指标;统计两组患者的不良反应总发生率。结果:观察组的中医治疗有效率为94.92%高于对照组的83.05%(P<0.05);观察组的意识恢复时间、中毒症状消失时间及肢体运动恢复时间均短于对照组(P<0.05);观察组治疗后,SpO_2和CaO_2水平均高于对照组(P<0.05),BrAC水平低于对照组(P<0.05);观察组治疗后,SOD和GSH-Px水平均高于对照组(P<0.05),MDA水平低于对照组(P<0.05);观察组的不良反应总发生率为10.17%低于对照组的22.03%(P<0.05)。结论:酒毒内蕴型AAI患者应用醒脑静治疗疗效显著,能显著缓解临床症状,降低BrAC水平,改善氧代谢和氧化应激相关指标,安全性高。
Objective:To explore the effect of Xingnaojing on breath alcohol concentration(BrAC)for patients with acute alcohol intoxication(AAI)of alcohol-toxicity implication type.Methods:A total of 118AAI patientsof alcohol-toxicity implication type who were admitted to the hospital from July 2016to July 2019were enrolled.They were divided into controlled group and observation group by random number table method,59cases in each group.The controlled group was treated with Naloxone,while the observation group was treated with Xingnaojing on the basis of the controlled group.The curative effect of TCM syndromes in both groups was statistically analyzed.The recovery time of consciousness,disappearance time of poisoning symptoms and recovery time of limbs motor after treatment in both groups were statistically analyzed and compared.The levels of blood oxygen saturation(SpO2),arterial blood oxygen(CaO2)and breath alcohol concentration(BrAC)before and after treatment were compared between the two groups.The oxidative stress related indexes such as superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)before and after treatment were compared between the two groups.The total incidence of adverse reactions in both groups was statistically analyzed.Results:The response rate of TCM treatment in the observation group was higher than that in the controlled group(94.92%vs 83.05%)(P<0.05).The recovery time of consciousness,disappearance time of poisoning symptoms and recovery time of limbs motor in the observation group were shorterthan those in the controlled group(P<0.05).After treatment,levels of SpO2 and CaO2 in the observation group were higher than those in the controlled group(P<0.05),while the level of BrAC was lower than that in the controlled group(P<0.05).After treatment,the levels of SOD and GSH-Px in the observation group were higher than those in the controlled group(P<0.05),while MDA level was lower than that in the controlled group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the controlled group(10.17%vs 22.03%)(P<0.05).Conclusion:The curative effect of Xingnaojing is significant on AAI patients of alcohol-toxicity implication type,which can significantly alleviate clinical symptoms,reduce Brac level,can improve oxygen metabolism and oxidative stress related indexes,with high safety.
作者
马君媛
MA Junyuan(Aba Tibetan and Qiang Autonomous Prefecture People's Hospital,Maerkang Sichuan 624000,China)
出处
《四川中医》
2020年第8期111-114,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
急性酒精中毒
酒毒内蕴型
醒脑静
纳洛酮
呼气酒精浓度
Acute alcohol intoxication
Alcohol-toxicity implication type
Xingnaojing
Naloxone
Breath alcohol concentration
