摘要
目的探讨老年原发性高血压(EH)伴腔隙性脑梗死患者血压变异性(BPV)特点及其与认知受损的关系。方法选取2017年1月至2018年4月在我院治疗的老年EH合并腔隙性脑梗死患者80例(观察组),同时选取单纯EH患者100例(对照组),均给予24 h动态血压监测,同时应用简易智能状态检查量表(MMSE)评估认知情况。结果观察组和对照组24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、白昼平均收缩压(dSBP)和白昼平均舒张压(dDBP)比较差异无统计学意义,差异无统计学意义(P>0.05);观察组夜间平均收缩压(nSBP)和夜间平均舒张压(nDBP)分别为(151.15±16.10)mmHg和(87.11±6.12)mmHg,明显高于对照组,差异有统计学意义(P<0.05);观察组24 h平均收缩压变异系数(24 h SBPV)、白昼平均收缩压变异系数(dSBPV)、夜间平均舒张压变异系数(nSBPV)、24 h平均舒张压变异系数(24 h DBPV)、白昼平均舒张压变异系数(dDBPV)和夜间平均舒张压变异系数(nDBPV)分别为(0.16±0.04)、(0.15±0.03)、(0.15±0.04)、(0.14±0.04)、(0.15±0.03)和(0.14±0.05),明显高于对照组,差异有统计学意义(P<0.05);观察组MMSE评分为(18.26±2.15)分,明显低于对照组,差异有统计学意义(P<0.05);nSBP、nDBP、nSBPV、nDBPV与MMSE评分呈弱正相关关系(r=0.298、0.301、0.281和0.295,P<0.05)。结论老年EH伴腔隙性脑梗死患者夜间SBP、DBP及血压变异性明显高于单纯EH患者,且与患者认知功能受损有一定关系。
Objective To investigate the characteristics of blood pressure variability(BPV)in elderly patients with essential hypertension(EH)and lacunar infarction and its relationship with cognitive impairment.Methods 80 elderly EH patients with lacunar infarction in our hospital from January 2017 to April 2018 were selected as observation group,and 100 EH patients were selected as control group,all patients were given 24-hour ambulatory blood pressure monitoring,mini mental state estimate(MMSE)was used to assess cognitive status.Results The 24-hour mean systolic blood pressure(24 h SBP),24-hour mean diastolic blood pressure(24 h DBP),daytime mean systolic blood pressure(dSBP)and daytime mean diastolic blood pressure(dDBP)in the observation group and the control group difference were nostatistical significance(P>0.05);The nighttime mean systolic blood pressure(nSBP)and nighttime mean diastolic blood pressure(nDBP)in the observation group were(151.15±16.10)mmHg and(87.11±6.12)mmHg,which were significantly higher than those in the control group(P<0.05);The 24-hour mean systolic pressure variation coefficient(24 h SBPV),diurnal mean systolic pressure variation coefficient(dSBPV),nighttime mean diastolic pressure variation coefficient(nSBPV),24-hour mean diastolic pressure variation coefficient(24h DBPV),diurnal mean diastolic pressure variation coefficient(dDBPV)and nighttime mean diastolic pressure variation coefficient(nDBPV)of the observation group were(0.16±0.04),(0.15±0.03),(0.15±0.04),(0.14±0.04),(0.15±0.03)and(0.14±0.05),were significantly higher than those in the control group(P<0.05);The MMSE score of the observation group was(18.26±2.15),which was significantly lower than that of the control group(P<0.05);nSBP,nDBP,nSBPV and nDBPV were weakly and positively correlated with MMSE scores(r=0.298,0.301,0.281 and 0.295,P<0.05).Conclusion The night SBP,DBP and blood pressure variability of elderly EH patients with lacunar infarction are significantly higher than those of simple EH patients,and are related to cognitive impairment.
作者
杨明刚
叶德祥
施学松
王发胜
Yang Minggang;Ye Dexiang;Shi Xuesong(Xuyi Hospital,Huaian,Jiangsu 211700,China)
出处
《四川医学》
CAS
2020年第7期744-747,共4页
Sichuan Medical Journal
关键词
原发性高血压
腔隙性脑梗死
血压变异性
认知受损
essential hypertension
lacunar infarction
blood pressure variability
cognitive impairment
