摘要
目的观察老年帕金森痴呆患者应用盐酸美金刚治疗的临床效果。方法选取2018年6月至2019年6月阳江市人民医院神经内科收治的老年帕金森痴呆患者70例,按照数字表法随机分为对照组与观察组,各35例。对照组应用盐酸多奈哌齐治疗,观察组应用盐酸美金刚治疗。分别于不同时间段(治疗前、治疗后第4、10、16周)对2组精神状态、日常生活能力与血清炎症因子水平进行观察。结果治疗后第4、10、16周时,2组蒙特利尔认知评估量表评分、简易智能状态检查量表与日常生活能力评分均提高(P<0.05),且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后第4、10、16周时,2组白细胞介素1β与肿瘤坏死因子α均下降(P<0.05),且观察组优于对照组,差异有统计学意义(P<0.05)。结论应用盐酸美金刚为老年帕金森痴呆患者进行治疗,可改善患者认知功能、精神状态与炎症反应,并促进其日常生活能力的提升。
Objective To explore the clinical effect of memantine hydrochloride in alzheimer's disease patients.Methods From June 2018 to June 2019,70 patients with Alzheimer's disease were selected from the Department of Neurology,Yangjiang people's hospital.They were divided into control group and observation group randomLy,35 cases in each group.The control group was treated with donepezil hydrochloride,and the observation group was treated with memantine hydrochloride.Cognitive function,mental state,daily life ability and serum inflammatory factor levels were observed in the two groups at different time periods(before treatment,4th,10th and 16th weeks after treatment).Results At the 4th,10th and 16th weeks after treatment,the score of the Montreal Cognitive Assessment,the Mini-mental State Examination scale and the daily life ability were all increased in the two groups,and the increase in the observation group was greater than that in the control group.The difference was statistically significant(P<0.05).At the 4th,10th and 16th weeks after treatment,the levels of IL-1βand TNF-αdecreased in the two groups,and the decrease in the observation group was higher than that in the control group(P<0.05).Conclusion Using memantine hydrochloride to treat senile patients with Alzheimer's disease can improve their cognitive function,mental state and inflammatory response,and promote their daily life ability.
作者
黄树栋
岑雄图
黄光位
HUANG Shudong;CEN Xiongtu;HUANG Guangwei(Yangjiang People's Hospital,Yangjiang,Guangdong 529500,China)
出处
《大医生》
2020年第4期4-7,共4页
Doctor
关键词
盐酸美金刚
老年帕金森痴呆
临床疗效
memantine hydrochloride
Alzheimer's disease
clinical efficacy
