摘要
目的探讨小儿耐甲氧西林金黄色葡萄球菌(MRSA)和甲氧西林敏感金黄色葡萄球菌(MSSA)感染病例临床特征与耐药性。方法选取2014年6月至2016年1月期间安徽省儿童医院就诊的264例金黄色葡萄球菌感染病儿,根据《全国临床检验操作规程(第3版)》推荐的抗生素药敏试验结果分为MRSA病例组149例,MSSA病例组115例,收集两组病例的人口学资料、血常规检测结果、C反应蛋白(CRP)值、感染部位和耐药性检测结果等数据并进行对比分析。结果 MRSA组住院天数为(13.8±10.2)d,MSSA组为(11.1±10.4)d;MRSA组CRP值为(48.4±56.9)mg/L,MSSA组为(30.0±41.5)mg/L;MRSA组败血症发生率为27.5%,MSSA组为13.0%;MRSA组呼吸道感染率为13.4%,MSSA组为4.3%;MRSA组在住院天数、CRP值、败血症发生率和呼吸道感染率高于MSSA组,差异有统计学意义(P<0.05);MRSA组对氨苄青霉素舒巴坦、阿莫西林/克拉维酸钾、头孢曲松、克林霉素、红霉素、四环素、复方磺胺甲唑和左氧氟沙星的耐药性高于MSSA组(P<0.05)。结论小儿MRSA病例在败血症发生率、呼吸道感染、CRP值和耐药性上高于MSSA病例。
Objective To analyze the clinical characteristics and drug resistant between the cases of Methicillin⁃Resistant Staphylo⁃coccus Aureus(MRSA)and Methicillin Sensitive Staphylococcus Aureus(MSSA).Methods A total of 264 staphylococcus aureus infection cases in Anhui Provincial Children’s Hospital from June 2014 to January 2016 were recruited and divided into 149 MRSA cases and 115 MSSA cases according to the antibiotic susceptibility test which was recommended by the Clinical and Labo⁃ratory Standards Institute.The data of demographic features,blood routine examination,C⁃reactive protein,infection position,and drug sensitive test were collected and compared between the two groups.Results The lengthen of stay in MRSA group was(13.8±10.2)days,while(11.1±10.4)days of MSSA group.The CRP value of MRSA group was(48.4±56.9)mg/L,and that of the MSSA group was(30.0±41.5)mg/L.The incidence of septicemia in MRSA group was 27.5%,while MSSA group was 13.0%.The incidence of respiratory infection was 13.4%in MRSA group and 4.3%in MSSA group.There were significant differences in the average length of stay,CRP value,septicemia and respiratory infection between MRSA and MSSA group(P<0.05).The MRSA group was with higher drug⁃resistant rate than MSSA group among ampicillin,amoxycillin⁃clavulanic acid,ceftriaxone,clindamycin,erythromy⁃cin,tetracycline,trimethoprim/sulfamethoxazole and levofloxacin(P<0.05).Conclusion The incidence of sepsis,respiratory tract infection,CRP and drug resistance in children with MRSA were significant higher than those with MSSA.
作者
赵晓玲
金丹群
朱玉林
ZHAO Xiaoling;JIN Danqun;ZHU Yulin(Department of Critical Care Medicine,Anhui Provincial Children’s Hospital,Hefei,Anhui 230051,China;Department of Pediatric,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China)
出处
《安徽医药》
CAS
2020年第9期1846-1849,共4页
Anhui Medical and Pharmaceutical Journal
关键词
耐甲氧西林金黄色葡萄球菌
致病力
微生物敏感性试验
婴儿
儿童
临床特征
Methicillin⁃resistant staphylococcus aureus
Pathogenicity
Microbial sensitivity tests
Infant
Child
Clinical features
