摘要
目的:探究复方丹参滴丸对老年冠心病患者血流变学、血脂及炎性反应递质的影响。方法:选取2015年1月至2017年12月海南省人民医院收治的老年冠心病患者154例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组77例。对照组采用常规西药治疗,观察组在此基础上加服复方丹参滴丸。比较治疗前后2组患者的血流变学、血脂、炎性反应递质和疗效。结果:观察组治疗有效率为92.21%,明显高于对照组治疗有效率79.22%,差异有统计学意义(P<0.05)。治疗后,2组总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白(LDL)水平均升高,差异有统计学意义(P<0.05),且观察组高于对照组,2组差异有统计学意义(P<0.05)。2组血流变学指标、高密度脂蛋白(HDL)、IL-6和TNF-α水平治疗后均降低(P<0.05),且观察组降低更明显,差异有统计学意义(P<0.05)。结论:复方丹参滴丸联合常规西药治疗冠心病患者,能够调节脂代谢,降低炎性反应,改善血流变学。
Objective:To explore the effects of Compound Danshen Dripping Pills on hemorheology,blood lipid and inflammatory factors in elderly patients with coronary heart disease.Methods:A total of 154 elderly patients with coronary heart disease admitted to Hainan People′s Hospital from January 2015 to December 2017 were randomly divided into an observation group(77 cases)and a control group(77 cases)according to random number table.The control group was treated with conventional Western medicine,while the observation group was given compound Danshen dripping pills on the basis of the control group.The hemorheology,blood lipid,inflammatory factors and curative effect were compared between the 2 groups.Results:The total effective rate in the observation group was 92.21%,significantly higher than that in the control group(79.22%)(P<0.05).After treatment,the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein(LDL)in the 2 groups increased(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).The hemorheology indexes,the levels of high density lipoprotein(HDL),IL-6 and TNF-αin the 2 groups decreased after treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Compound Danshen Dripping Pills combined with conventional Western medicine can regulate lipid metabolism,reduce inflammatory reaction and improve hemorheology in elderly patients with coronary heart disease,which is worthy of being recommended.
作者
黄修献
林泽辉
李海涛
李斌
王圣
王裕岱
HUANG Xiuxian;LIN Zehui;LI Haitao;LI Bin;WANG Sheng;WANG Yudai(Department of Cardiology,Hainan People′s Hospital,Haikou 570103,China;Emergency Department of Hainan Traditional Chinese Medicine Hospital,Haikou 570103, China)
出处
《世界中医药》
CAS
2020年第16期2438-2442,共5页
World Chinese Medicine
基金
海南省自然科学基金创新研究团队项目(SQ2016LCXD0010)。
关键词
复方丹参滴丸
老年
冠心病
血液流变学
总胆固醇
高密度脂蛋白
三酰甘油
低密度脂蛋白
Compound Danshen dripping Pills
Elderly
Coronary heart disease
Hemorheology
Total cholesterol
High density lipoprotein
Triglyceride
Low density lipoprotein
