摘要
目的 :探讨尼可地尔联合氨氯地平治疗高血压合并早期肾损害的临床疗效。方法 :选取86例高血压合并早期肾损害患者作为研究对象,按照随机数字表法分为对照组与试验组各43例。对照组给予氨氯地平治疗,试验组给予尼可地尔联合氨氯地平治疗,比较两组的临床疗效。结果 :治疗后,试验组的β2-MG、UCr、SCr、BUN值及SBP、DBP值明显低于对照组(P <0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论 :高血压合并早期肾损害患者给予尼可地尔联合氨氯地平治疗,不但能有效改善肾功能,而且还能对患者血压水平进行有效控制,不良反应无明显增加,具有较高的安全性。
Objective:To investigate the clinical effect of nicorandil combined with amlodipine in the treatment of hypertension with early renal damage.Methods:Eighty patients with hypertension complicated with early renal damage were selected as the research objects and randomly divided into a control group and an experimental group with 43 cases each.The control group was treated with amlodipine while the experimental group with nicorandil combined with amlodipine.Results:The b2-MG,UCR,SCR,BUN,SBP and DBP values were significantly lower in the experimental group than the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination therapy can effectively not only improve renal function,but also control the blood pressure level of patients,and has high safety without the significant increase of the adverse reactions.
作者
杨春兰
彭丽华
关燕
YANG Chunlan;PENG Lihua;GUAN Yan(Zhengzhou Center for Disease Control and Prevention,Zhengzhou 450007,China)
出处
《上海医药》
CAS
2020年第17期11-13,共3页
Shanghai Medical & Pharmaceutical Journal
