摘要
目的探讨肝功能检验评估替比夫定治疗乙型病毒性肝炎的价值。方法选取2018年2月至2019年4月期间收治的乙型病毒性肝炎患者90例,均接受替比夫定治疗,分别于治疗前1天和治疗8周后抽取患者晨起空腹静脉血,使用全自动生化分析仪测定肝功能指标,包括谷丙转氨酶(ATL)、谷草转氨酶(AST)、白蛋白(ALB)、总胆红素(TBIL);采用化学发光法测定血清肝纤维化指标,包括:透明质酸、层黏连蛋白、Ⅲ型前胶原、Ⅳ型胶原。结果治疗后患者的ATL、AST、ALB、TNIL水平36.44±10.68、40.75±10.95、39.49±8.54、13.48±6.18均较治疗前218.48±40.15、181.45±18.26、28.45±10.65、38.05±10.84,差异有统计学意义(t=,P<0.05);治疗后患者的透明质酸(96.25±20.54)、层黏连蛋白(76.15±13.24)、Ⅲ型前胶原(15.25±4.56)、Ⅳ型胶原(80.15±24.87)水平均低于治疗前(188.45±49.25)、(157.05±39.18)、(80.48±15.48)、(188.48±48.27),差异有统计学意义(t=,P<0.05)。结论乙型病毒性肝炎患者药物治疗后,经检验患者肝功能指标均明显改善,肝纤维化得到有效抑制,效果显著。
Objective To investigate the changes of liver function indexes before and after treatment with telbivudine in patients with viral hepatitis B.Methods Ninety patients with viral hepatitis B admitted between February 2018 and April 2019 were selected,and all received telbivudine treatment.The fasting venous blood from the patients was drawn one day before the treatment and 8 weeks after the treatment.Use automatic biochemical analyzer to measure liver function indicators,including alanine aminotransferase(ATL),aspartate aminotransferase(AST),albumin(ALB),total bilirubin(TBIL);use chemiluminescence method to determine serum liver fibrosis indicators,Including:hyaluronic acid,laminin,typeⅢprocollagen,typeⅣcollagen.Results After treatment,the ATL,AST,ALB,TNIL levels of(36.44±10.68),(40.75±10.95),(39.49±8.54),(13.48±6.18)were higher than before treatment(218.48±40.15),(181.45±18.26),(28.45±10.65),(38.05±10.84),the difference was Statistical significance(t=,P<0.05);Hyaluronic acid(96.25±20.54),laminin(76.15±13.24),typeⅢprocollagen(15.25±4.56),typeⅣcollagen(80.15±24.87)The level was lower than before treatment(188.45±49.25),(157.05±39.18),(80.48±15.48),(188.48±48.27),the difference was statistically significant(t=,P<0.05).Conclusion After drug treatment for patients with viral hepatitis B,the liver function indexes of the patients were significantly improved,and liver fibrosis was effectively suppressed,and the effect was significant.
作者
赵轲
ZHAO Ke(Clinical Laboratory of Jiaozuo No.3 Peoples Hospital,Jiaozuo,Henan 454000,China)
出处
《医药论坛杂志》
2020年第8期65-67,共3页
Journal of Medical Forum
