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度洛西汀联合拉莫三嗪在难治性抑郁症治疗中的应用研究 被引量:12

Application effects of duloxetine combined with lamotrigine in treatment of treatment refractory depression
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摘要 目的观察度洛西汀联合拉莫三嗪在难治性抑郁症(treatment-refractory depression,TRD)治疗中的应用效果。方法选取2018年1月至2019年1月收治的TRD患者80例,使用随机数字表法分为治疗1、2组,分别给予度洛西汀联合拉莫三嗪治疗及单独使用度洛西汀治疗,2组均连续治疗8周。使用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)及临床总体印象量表(clinical global impression scale,CGI)评价治疗前及治疗后2、4、6、8周临床效果,使用不良反应症状量表(treatment emergent symptom Scale,TESS)对治疗期间药物安全性进行评价。结果2组治疗前HAMD及CGI评分对比具有可比性(P>0.05),治疗后2、4、6、8周时HAMD及CGI评分均明显下降,与治疗前比较差异有统计学意义(P<0.05);治疗1组治疗后4、6、8周时HAMD及CGI评分低于治疗2组,组间比较差异有统计学意义(P<0.05);2组治疗8周后临床痊愈率及显效率比较差异无统计学意义(P>0.05),治疗1组治疗8周后总有效率高于治疗2组,组间比较差异有统计学意义(P<0.05);治疗8周时使用TESS量表进行药物耐受及不良反应发生情况进行评价,结果显示2组患者治疗期间各种不良反应发生率比较差异均无统计学意义(P>0.05)。结论度洛西汀联合拉莫三嗪可有缓解RTD患者抑郁症状,提高疗效,值得在临床推广使用。 Objective To investigate the application effects of duloxetine combined with lamotrigine in treatment of treatment refractory depression(TRD).Methods A total of 80 patients with TRD who were treated in our hospital from January 2018 to January 2019 were enrolled in the study,who were randomly divided into treatment group 1 and treatment group 2.The patients in treatment group 1 were treated by duloxetine combined with lamotrigine,however,the patients in treatment group 2 were treated by simple duloxetine,with a treatment course of 8 weeks for both groups.The HAMD and CGI were used to evaluate the clinical curative effects before treatment,at 2w,4w,6w,and 8w after treatment.Moreover the TESS was used to evaluate the drug safety during treatment.Results There was comparability in HAMD and CGI scores before treatment between the two groups(P>0.05).After treatment the HAMD scores and CGI scores at 2w,4w,6w,and 8w were significantly decreased in both groups(P<0.05).And the HAMD scores and CGI scores at 4w,6w,and 8w after treatment in treatment group 1 were significantly lower than those in treatment group 2(P<0.05).There were no significant differences in clinical cure rate and effective rate at 8w after treatment between the two groups(P>0.05).The total effective rate at 8w after treatment in treatment group 1 were significantly higher than those in treatment group 2(P<0.05).There were no significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion The duloxetine combined with lamotrigine in treatment of RTD can effectively alleviate the depression symptoms and improve the therapeutic effects,therefor,it is worthy of clinical application and promotion.
作者 谷丛欣 李素水 范彦蓉 刘海凤 王艳辉 GU Congxin;LI Sushui;FAN Yanrong(The Eighth Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050081,China)
出处 《河北医药》 CAS 2020年第16期2507-2509,共3页 Hebei Medical Journal
关键词 度洛西汀 拉莫三嗪 TRD HAMD CGI duloxetine lamotrigine TRD HAMD CGI
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  • 1任红英.难治性抑郁症患者MECT治疗的护理效果分析[J].今日健康,2016,15(10):237-237. 被引量:1
  • 2张璐璐,郑洪波.盐酸度洛西汀介绍[J].临床精神医学杂志,2007,17(4):284-285. 被引量:34
  • 3O'Leary OF, Dinah TG, Cryan JF. Faster, better, stronger : towards new antidepressant therapeutic strategies [ J ]. Eur J Pharmacol, 2015,753:32-50. DOI: 10. lO16/j.ejphar.2014.07.046.
  • 4Montgomery SA, Nielsen RZ, Poulsen LH, et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin re- uptake inhibitor or serotonin-noradrenaline reuptake inhibitor treat- ment switched to vortioxetine or agomelatine [ J ]. Hum Psychophar-maeo1,2014,29 ( 5 ) :470-482. DOI : 10.1002/hup.2424.
  • 5Blum SI, Tourkodimitris S, Ruth A. Evaluation of functional health and well-being in patients receiving levomilnacipran ER for the treatment of major depressive disorder [ J ]. J Affect Disord, 2015, 170:230-236. DOt : 10.1016/j.jad.2014.09.005.
  • 6Asnis GM, Henderson MA. Levomilnacipran for the treatment of major depressive disorder: a review [ J ]. Neuropsyehiatr Dis Treat, 2015,11 : 125-135. DOI : 10.2147/NDT.S54710.
  • 7Learned S, Craft O, Roychowdhury S, et al. Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treat- ment of patients with major depressive disorder: two randomized, placebo- and active-controlled clinical trials[J]. J Psychopharma- col, 2012,26 ( 5 ) : 653 -662. DOI : 10.1177/0269881111424931.
  • 8Wang Y, Chang T, Chen YC, et al. Quetiapine add-on therapy im- proves the depressive behaviors and hippocampal neurogenesis in fluoxetine treatment resistant depressive rats[ J]. Behav Brain Res, 2013,253:206-211. DOI : 10.1016/j.bbr.2013.07.021.
  • 9Lenze EJ, Mulsant BH, Blumberger DM, et al. Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life : a randomised, double- blind, placebo-controlled trial [ J ]. Lancet, 2015, 386 ( 10011 ) : 2404-2412. DOI : 10.1016/S0140-6736 ( 15 ) 00308-6.
  • 10Tamayo JM, Pica-Ruiz Y, Ruiz I. Olanzapine and fluoxetine com- bined as therapy for treatment-resistant depression: a systematic review[ J]. Arch Neurocien ,2015,20( 1 ) : 17-33.

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