摘要
目的评价注射用丹参多酚酸对辨证为血瘀型的急性脑梗死患者的临床疗效与安全性。方法选取2018年7月—2019年7月安阳市中医院收治的辨证为血瘀型的急性脑梗死患者85例,随机分为对照组(43例)与观察组(42例)。对照组给予调血压、降血糖等基础治疗,观察组在对照组基础上加用注射用丹参多酚酸0.13 g溶于250 mL氯化钠溶液中静滴1次/d,两组疗程均14 d。比较两组患者美国国立卫生研究院卒中量表(NIHSS)、日常生活活动能力(ADL)评分、缺血半暗带、临床疗效及不良反应。结果治疗前两组患者缺血半暗带、NIHSS和ADL评分无统计差异。治疗后,两组患者缺血半暗带、NIHSS和ADL评分均有改善(P<0.05),且观察组这3个指标改善程度均优于对照组(P<0.05);观察组临床总有效率为93%,明显高于对照组的77%(P<0.05);观察组中医血瘀证候疗效的总有效率为95.2%,明显高于对照组的72.0%(P<0.05)。两组均无不良反应发生。结论注射用丹参多酚酸对血瘀型急性脑梗死患者的疗效明显,可能是基于对缺血半暗带的有效治疗而发挥神经保护作用。
Objective To observe the clinical efficacy and safety of Salvianolic Acid for Injection in the treatment of acute cerebral infarction belong to blood stasis syndrome in traditional Chinese medicine.Methods A total of 85 patients with acute cerebral infarction belong to blood stasis syndrome in Traditional Chinese Medicine(TCM)in Anyang Traditional Chinese Medicine Hospital from July 2018 to July 2019 were selected and divided randomly into control group(43 cases)and observation group(42 cases).The control group was given antiplatelet aggregation,blood pressure and blood glucose control,free scavenger drugs.The observation group treated with Salvianolic Acid for Injection 0.13 g added into 250 mL sodium chloride injection for intravenous infusion once a day on the basis of control group.Both groups were treated for 2 weeks.The NIHSS scores,ADL scores,ischemic penumbra,therapeutic effects,and adverse reactions were compared between two groups before and after treatment.Results The NIHSS scores,ADL scores,and ischemic penumbra were no statistical difference between two groups before treatment.After treatment,the ischemic penumbra,NIHSS and ADL scores in two groups were improved(P<0.05),and the three indexes in observation group were better than those in control group(P<0.05).The clinical total effective rate in observation group was 93%,while it was 77%in control group,observation group was significantly higher than control group(P<0.05).The syndrome of blood stasis in TCM total effective rate in observation group was 95.2%,while it was 72.0%in control group,observation group was significantly higher than control group(P<0.05).There was no adverse reactions in two groups.Conclusion the therapeutic effect of Salvianolic Acid for Injection in the treatment of acute cerebral infarction is exact,which may be based on the effective treatment of ischemic penumbra after acute cerebral infarction and play a neuroprotective role.
作者
刘良敏
李林
张慧永
陈曦光
康朋
张巾
宋文俊
LIU Liangmin;LI Lin;ZHANG Huiyong;CHEN Xiguang;KANG Peng;ZHANG Jin;SONG Wenjun(First Department of Encephalopathy,Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,China)
出处
《药物评价研究》
CAS
2020年第8期1623-1626,共4页
Drug Evaluation Research
