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自动化腹膜透析对终末期肾衰竭患者心功能和临床症状的影响 被引量:15

Effect of automated peritoneal dialysis on cardiac function and clinical symptoms in patients with end-stage renal failure
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摘要 目的:研究自动化腹膜透析(APD)对终末期肾衰竭(ESRF)患者心功能和临床症状的影响。方法:选择ESRF患者40例,按透析方式分为人工组及自动组,各20例。人工组采用持续性非卧床腹膜透析(CAPD),自动组采用APD。治疗2周后复查有关指标。对比两组患者疗效、生活质量、并发症发生率、血钙(Ca 2+)水平、血磷(P 3+)水平、钙磷乘积水平、免疫功能水平、心功能指标。结果:自动组治疗总有效率高于人工组(P<0.05)。自动组治疗后Ca 2+、P 3+、钙磷乘积水平均低于人工组(P<0.05)。自动组治疗后成熟T淋巴(CD 3+)细胞水平、辅助性T淋巴(CD 4+)细胞水平均高于人工组,自然杀伤(NK)细胞水平低于人工组(P<0.05)。自动组治疗后左心室射血分数高于人工组,心衰敏感标记物B型钠尿肽(BNP)水平低于人工组(P<0.05)。自动组治疗后生活质量评分均高于人工组(P<0.05)。两组患者并发症发生率比较,差异无统计学意义(P>0.05)。结论:自动化腹膜透析治疗ESRF患者可有效改善心功能及临床症状。 Objective:To study the effect of automated peritoneal dialysis(APD)on cardiac function and clinical symptoms in patients with end-stage renal failure(ESRF).Methods:40 patients with ESRD were selected and divided into artificial group and automatic group according to the dialysis method,20 cases each.Continuous ambulatory peritoneal dialysis(CAPD)was used in the artificial group and APD was used in the automatic group.Relevant clinical indicators were reviewed after 2 weeks of treatment.The therapeutic effect,quality of life,incidence of complications,serum calcium(Ca 2+)level,blood phosphorus(P 3+)level,calcium-phosphorus product level,immune function level and cardiac function indicators were compared between the two groups.Results:The total effective rate of the automatic group was higher than that of the artificial group(P<0.05).The levels of Ca 2+,P 3+and calcium-phosphorus product of the automatic group were lower than those of the artificial group(P<0.05).The levels of CD 3+and CD 4+cells in the automatic group were higher than those in the artificial group,and the level of natural killer(NK)cells was lower than that in the artificial group(P<0.05).The left ventricular ejection fraction in the automatic group was higher than that in the artificial group,and the level of heart failure sensitivity marker type B natriuretic peptide(BNP)was lower than that in the artificial group(P<0.05).The quality of life score after treatment in the automatic group was higher than that in the artificial group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Automated peritoneal dialysis can effectively improve cardiac function and clinical symptoms in patients with ESRF.
作者 张志勇 李明旭 于海 肖枫林 玄方 赵君 ZHANG Zhiyong;LI Mingxu;YU Hai(Department of Nephrology,the Sixth Medical Center of PLA General Hospital,Beijing 100048)
出处 《陕西医学杂志》 CAS 2020年第9期1130-1133,共4页 Shaanxi Medical Journal
关键词 自动化腹膜透析 人工腹膜透析 终末期肾衰竭 心功能 临床症状 生活质量 Automated peritoneal dialysis Artificial peritoneal dialysis End-stage renal failure Heart function Clinical symptoms Quality of life
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