摘要
目的:探讨氨磺必利在治疗老年患者精神分裂症的临床疗效及安全性。方法:分析78例老年精神分裂症患者的临床资料,根据药物治疗方案的不同将患者分为观察组(n=37)和对照组(n=41),其中观察组患者采用氨磺必利药物治疗,对照组患者采用喹硫平方案治疗。采用PANSS量表评定患者的临床疗效;采用副反应量表(TESS)评定治疗期间的不良反应和ADL量表(Barthel指数)评定患者的生活质量。分析比较两组患者在治疗前和治疗后4周、8周、12周的临床疗效,及治疗后12周的不良反应和生活质量。结果:观察组患者显效率为56.7%,有效率为89.1%;对照组患者显效率为56.1%,有效率为85.4%,两组显效率、有效率比较,差异均无统计学意义(P>0.05)。治疗前,两组患者PANSS量表各症状间比较,差异无统计学意义(P>0.05);治疗后,两组患者的评分均下降,差异有统计学意义(P<0.05),但两组患者在治疗后同时期比较,差异无统计学意义(P>0.05)。治疗后,两组患者生活自理能力均显著提高,但观察组患者生活质量提高的程度高于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应率为21.6%;低于对照组的43.9%,差异有统计学意义(χ2=4.345,P=0.037)。结论:氨磺必利和喹硫平对于老年患者精神分裂症的治疗均有着较好的疗效,但氨磺必利能减少药物不良反应的发生,值得临床应用。
Objective:To investigate the clinical efficacy and safety of amisulpride in the treatment of schizophrenia in elderly patients.Methods:The clinical data of 78 elderly patients diagnosed as schizophrenia were retrospectively analyzed.Patients were divided into observation group(n=37)and control group(n=41)according to different drug treatment plans.Patients in observation group were treated with Amisulpride,the control group patients treated with quetiapine.PANSS scale was used to evaluate the clinical efficacy,TESS was used to evaluate the adverse reactions during treatment,and Barthel index was used to evaluate the quality of life.The clinical efficacy of the PANSS was assessed before and 4 w,8 w and 12 w after treatment in both groups,and the adverse reactions and quality of life after 12 w of treatment.Results:The markedly effective rate and the effective rate of the observation group were 56.7%and 89.1%,respectively,while those of the control group were 56.1%and 85.4%,respectively.There was no significant difference between the two groups(P>0.05).There was no significant difference between the two groups before the treatment of PANSS symptoms,the scores of both groups decreased after treatment,and compared with before treatment were statistically significant(P<0.05),there wes no significant difference between the two groups in the same period after treatruent(P>0.05).Both groups of patients had significantly improved self￣care ability after treatment,but the quality of life of patients in the observation group was higher than that of the control group.The comparison was statistically significant(P<0.05).The adverse reaction rate of the observation group was 21.6%,which was lower than 43.9%of the control group,the difference was statistically significant(χ2=4.345,P=0.037).Conclusion:Amisulpride and Quetiapine have a good effect in the treatment of schizophrenia in elderly patients,but Amisulpride can reduce the incidence of adverse drug reactions and is worthy of priority in clinical application.
作者
丁永红
邓金英
周庆海
DING Yong-hong;DENG Jin-ying;ZHOU Qing-hai(Department of Andrology II,the Third People's Hospital of Shangrao,Shangrao 334000,Jiangxi,China)
出处
《川北医学院学报》
CAS
2020年第4期675-678,共4页
Journal of North Sichuan Medical College
