摘要
目的分析肝原发性腺鳞癌(ASC)患者临床和组织病理学特征。方法回顾性分析6例肝ASC患者的临床资料,采取肝叶切除或/和经动脉化疗栓塞治疗,采用SP法检测蛋白表达。结果在6例患者中,男性2例,女性4例;年龄为54~75岁,平均年龄为(63.0±8.3)岁;临床均以腹痛为首发表现,影像学检查发现肝内占位性病变;肿瘤组织肉眼观呈灰白色、实性,边界较清晰;镜下见瘤细胞呈巢状或腺管状;6例肝组织腺癌区域均表达CK7、CK19、cam5.2和Ki-67,4例表达CEA,3例表达CK20,2例表达CDX-2,1例表达MUC-1;鳞癌区域均表达p40、p63和CK5/6,4例弱阳性表达CK19,3例弱阳性表达EMA;术后平均生存6个月。结论肝原发性腺鳞癌主要依靠病理学检查诊断,其恶性程度较高,患者生存期短。
Objective The aim of this study was to analyze the clinicopathological features of patients with primary adenosquamous carcinoma(ASC)of liver.Methods The clinical and histopathological data of 6 patients with ASC were analyzed retrospectively,and all patients received hepatectomy and/or TACE.The hepatic tissue protein expression was detected by SP.Results In the six patients,two were women and four women,aged 54-75 yr with an average age of(63.0±8.3)yr;all patients presented with abdominal pain and intrahepatic foci were found by imaging examination;the gross foci mass was grayish white and solid with a relative clear border;the tumor cells were nested or glandular tubular microscopically;the SP detection showed the hepatic CK7,CK19,cam5.2 and Ki-67 positive in six,CEA positive in four,CK20 in three,CDX-2 in two and MUC-1 in one;the overall survival was 6 months.Conclusion The diagnosis of primary ASC of liver depends on the pathological examination,the tumor is malignant and the survival of patients is short.
作者
刘旭
胡余昌
陈路
刘宇飞
吴琪
Liu Xu;Hu Yuchang;Cheng Lu(Institute of Pathology,Sanxia University,Yichang 443001,Hubei Province,China)
出处
《实用肝脏病杂志》
CAS
2020年第5期727-730,共4页
Journal of Practical Hepatology
基金
湖北省重点实验室开放基金资助项目(编号:2018KZL03)
湖北省高等学校省级教学研究项目(编号:2017260)。
关键词
肝腺鳞癌
组织病理学
蛋白表达
免疫组织化学
Hepatoma
Primary adenosquamous carcinoma
Histopathology
Immunohistochemistry
