摘要
目的:观察硝普钠联合多巴胺治疗心力衰竭患者的效果。方法:选取60例心力衰竭患者为研究对象,按照随机数字表法分为观察组与对照组,每组30例。对照组在常规治疗基础上给予硝普钠治疗,观察组在对照组基础上给予多巴胺治疗,比较两组临床疗效、血流动力学指标[心排血量(CO)、心率(HR)及中心静脉压(CVP)]水平、C反应蛋白(CRP)水平、脑利钠肽(BNP)水平、左心室射血分数(LVEF)水平和不良反应发生率。结果:观察组治疗有效率为90.00%,明显高于对照组的40.00%,差异有统计学意义(P<0.05);治疗后,两组CO和LVEF水平明显高于治疗前,且观察组高于对照组;两组HR、CVP、CRP和BNP水平明显低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:硝普钠联合多巴胺治疗心力衰竭患者可提高治疗总有效率、CO和LVEF水平,以及降低HR、CVP、CRP和BNP水平,效果优于单纯硝普钠治疗效果。
Objective:To study effects of Sodium nitroprusside combined with Dopamine in treatment of patients with heart failure.Methods:60 patients with heart failure were selected as the research objects.According to the random number table method,they were divided into observation group and control group,30 cases in each group.The control group was treated with Sodium nitroprusside on the basis of conventional treatment,while the observation group was treated with Dopamine on the basis of those of control group.Then,the clinical efficacy,hemodynamic indicators[cardiac output(CO),heart rate(HR)and central venous pressure(CVP)]levels,C-reactive protein(CRP)level,brain natriuretic peptide(BNP)level,left ventricular ejection fraction(LVEF)level and incidence of adverse reactions were compared between the two groups.Results:The effective rate of treatment in the observation group was 90.00%,which was significantly higher than 40.00%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CO and LVEF in the two groups were significantly higher than those before the treatment,and those of the observation group were higher than those of the control group;the levels of HR,CVP,CRP and BNP in the two groups were significantly lower than those before the treatment,and those of the observation group were lower than those of the control group;and the differences were both statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Sodium nitroprusside combined with Dopamine in the treatment of the patients with heart failure can increase the effective rate and CO and LVEF levels,and reduce the levels of HR,CVP,CRP and BNP.Moreover,it is superior to single Sodium nitroprusside.
作者
李建有
LI Jianyou(Department of Cardiovascular Internal Medicine of Haicheng Central Hospital,Haicheng 114200 Liaoning,China)
出处
《中国民康医学》
2020年第14期18-19,22,共3页
Medical Journal of Chinese People’s Health
关键词
心力衰竭
硝普钠
多巴胺
Heart failure
Sodium nitroprusside
Dopamine
Therapeutic effect
