摘要
目的探讨氯吡格雷及阿司匹林辅助静脉溶栓治疗急性心肌梗死(AMI)患者的效果。方法选取2017年7月至2019年7月大连九洲世纪医院收治的100例急性ST段抬高型心肌梗死患者随机分为观察组(50例,采用阿替普酶静脉溶栓+阿司匹林+氯吡格雷治疗)和对照组(50例,采用阿替普酶静脉溶栓+阿司匹林治疗),比较两组治疗效果。结果观察组治疗有效率显著高于对照组(P<0.05),观察组心脑血管不良事件发生率和药物不良反应发生率显著低于对照组(P<0.05);两组患者治疗后各时间点N末端B型利钠肽原(NT-proBNP)指标得到显著改善(P<0.05);治疗后1周及1个月两组肌酸激酶同工酶(CK-MB)指标显著高于治疗前,但治疗后1周及1个月比较差异无统计学意义(P>0.05);治疗后1个月两组左心室射血分数(LVEF)指标显著高于治疗前和治疗后1周(P<0.05),但治疗后1周与治疗前比较差异无统计学意义(P>0.05);且治疗后各时间点观察组NT-proBNP、CK-MB指标显著优于对照组(P<0.05),治疗后1个月观察组LVEF显著高于对照组(P<0.05)。结论氯吡格雷及阿司匹林辅助静脉溶栓治疗急性ST段抬高型心肌梗死安全有效。
Objective To explore the effects of clopidogrel and aspirin combined with intravenous thrombolysis on patients with acute myocardial infarction. Methods A total of 100 cases of patients with acute ST segment elevation myocardial infarction in Dalian Jiuzhou Century Hospital were randomly divided into a control group(50 cases, using aspirin combined with intravenous thrombolysis) and an observation group(50 cases, using clopidogrel and aspirin combined with intravenous thrombolysis). The effects were compared between 2 groups. Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05), and the incidence of cardio-cerebrovascular adverse events and adverse drug reactions in the observation group were significantly lower than those in the control group(P<0.05). N-terminal B-type natriuretic peptide(NT-proBNP) index was significantly improved at each time point after treatment in the 2 groups of patients(P<0.05). One week and one month after treatment, CK-MB in both groups was significantly higher than that before treatment(P<0.05), but there was no significant difference one week and one month after treatment(P>0.05). One month after treatment, LVEF in both groups was significantly higher than that before treatment and one week after treatment(P<0.05), but there was no significant difference between one week after treatment and before treatment(P>0.05). The indexes of NT-proBNP, CK-MB in the observation group were significantly better than those in the control group at each time point after treatment(P<0.05). The LVEF of the observation group was significantly higher than that of the control group 1 month after treatment(P<0.05). Conclusion Clopidogrel and aspirin combined with intravenous thrombolysis has great effects on patients with Acute ST segment elevation myocardial infarction.
作者
李静珊
秦箐
李忠亮
LI Jing-Shan;QIN Qing;LI Zhong-Liang(Pharmacy Department,Dalian Jiuzhou Century Hospital,Dalian 116400,China;Department of Natural Pharmaceutical Chemistry,School of Pharmacy,Guangxi Medical University,Nanning 530021,China)
出处
《中国药物经济学》
2020年第7期98-100,104,共4页
China Journal of Pharmaceutical Economics
关键词
急性ST段抬高型心肌梗死
静脉溶栓
阿替普酶
阿司匹林
氯吡格雷
Acute ST segment elevation myocardial infarction
Intravenous thrombolysis
Alteplase
Aspirin
Clopidogrel
