摘要
目的探讨长期口服抗精神病药物患者的血液生化指标变化情况。方法选取2017年4月至2019年1月湖南师范大学附属长沙医院收治的长期服用抗精神病药患者88例作为研究对象,按治疗方法不同分为氯丙嗪组、氯氮平组、奥氮平组、利培酮组,各22例。比较4组患者治疗6个月后血液生化指标、体重指数(BMI)以及高血压、糖尿病、血脂异常、肝功能异常发生情况。结果治疗6个月后4组血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)、总胆固醇(TC)、碱性磷酸酶(ALP)、体重指数(BMI)明显高于正常值,差异有统计学意义(P<0.05);4组高血压、糖尿病、血脂异常与肝功能异常发生率比较,差异无统计学意义(P>0.05)。结论长期口服抗精神病药物患者的血液生化指标会显著升高,BMI增高,高血压、糖尿病、血脂异常与肝功能异常发病率增高。
Objective To explore the changes of blood biochemical indexes in patients with long-term oral antipsychotic drugs. Methods A total of 88 patients taking antipsychotic drugs for a long period of time in Changsha Hospital Affiliated to Hunan Normal University from April 2017 to January 2019 were selected as research subjects and according to different treatments were divided into a chlorpromazine group, a clozapine group, an olanzapine group, and a risperidone group,with 22 cases in each group. The blood biochemical indexes, BMI index, and the abnormal occurrence of hypertension, diabetes, dyslipidemia, and liver function were compared among the 4 groups after 6 months of treatment. Results After 6 months of treatment, serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), total protein(TP), albumin(ALB), total cholesterol(TC), alkaline phosphatase(ALP), the body mass index(BMI) were significantly higher than the normal value, and the difference was statistically significant(P<0.05);the incidence of hypertension, diabetes, dyslipidemia and liver function abnormality in the 4 groups was not statistically significant(P>0.05). Conclusion Patients with long-term oral antipsychotic drugs will have significantly higher blood biochemical indicators, increased BMI, and increased incidence of hypertension, diabetes, dyslipidemia, and abnormal liver function.
作者
彭程
彭聪
PENG Cheng;PENG Cong(Changsha Hospital Affiliated to Hunan Normal University,Changsha 410000,Hunan)
出处
《中国药物经济学》
2020年第7期109-111,共3页
China Journal of Pharmaceutical Economics
关键词
抗精神病药物
长期
生化指标
Antipsychotic drugs
Long-term
Blood
Biochemical indicators
