摘要
目的探讨开放性食物激发试验(OFC)在消化道牛奶蛋白过敏症婴儿中的应用。方法选取2018年1月~2020年3月我院收治的50例疑似消化道牛奶蛋白过敏症的患儿作为研究对象,住院后均使用牛奶蛋白实施OFC。分析50例患儿的临床特征和OFC试验结果。结果50例患儿的OFC结果显示,阴性4例(8.00%),阳性46例(92.00%)。其中迟发型过敏反应41例(89.13%),速发型过敏反应5例(10.87%)。50例患儿中,血便27例(54.00%),腹泻25例(50.00%),呕吐5例(10.00%),皮疹3例(6.00%),拒奶2例(4.00%)。阴性组和阳性组患儿的月龄、性别、临床表现比较,差异无统计学意义(P>0.05)。阴性组和阳性组患儿激发试验前后的中性粒细胞、白细胞、血小板水平比较,差异无统计学意义(P>0.05);阳性组激发试验后的中性粒细胞水平为(3.48±1.64)×109/L,高于激发试验前的(2.52±1.07)×109/L,差异有统计学意义(P<0.05)。结论OFC试验阴性可排除激发食物所致的消化道食物过敏,指导临床尽早进行干预,避免不必要的饮食回避,有利于患儿身体尽早康复。
Objective To explore the application of open food provocation test(OFC)in infants with digestive tract milk protein allergy.Methods From January 2018 to March 2020,50 children with suspected digestive tract milk protein allergies were selected as the research objects.After hospitalization,milk protein was used to implement OFC.The clinical characteristics and OFC test results of 50 children were analyzed.Results OFC results of 50 cases showed that 4 cases were negative(8.00%)and 46 cases were positive(92.00%).Among them,there were 41 cases(89.13%)with delayed anaphylaxis and 5 cases(10.87%)with tachycardia.Among the 50 cases,27 cases were blood stool(54.00%),25 cases were diarrhea(50.00%),5 cases were vomiting(10.00%),3 cases were rash(6.00%),and 2 cases were milk rejection(4.00%).There were no significant differences in monthly age,sex and clinical manifestations between the negative group and the positive group(P>0.05).There were no significant differences in neutrophil,white blood cell and platelet levels between the negative group and the positive group before and after the stimulation test(P>0.05).The level of neutrophils in the positive group after stimulation test was(3.48±1.64)×109/L,which was higher than that before stimulation test of(2.52±1.07)×109/L,with statistically significant difference(P<0.05).Conclusion A negative OFC test can rule out digestive food allergies caused by provocative foods,guide clinical interventions as soon as possible,avoid unnecessary dietary avoidance,and help children recover as soon as possible.
作者
乐庆胜
樊小燕
张小雯
邵军
LE Qing-sheng;FAN Xiao-yan;ZHANG Xiao-wen;SHAO-jun(Department of Pediatric Gastroenterology,Jiujiang Maternal and Child Health Hospital,Jiangxi Province,Jiujiang332000,china)
出处
《中国当代医药》
2020年第24期134-137,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20187142)。
