摘要
目的:观察复方甘草酸苷胶囊预防抗结核药物所致肝损伤的临床效果。方法:选择我院2018年6月—2018年12月确诊为肺结核且肝功能情况正常的患者80例,按随机数字表法分为对照组和观察组,各40例。在抗结核方法相同的条件下,对照组给予葡醛内酯口服,观察组给予复方甘草酸苷胶囊口服,检测肝功能,包括谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、谷氨酰转肽酶(GGT)等指标,以及肝损伤发生情况。结果:治疗后,观察组患者肝功能各项指标均优于对照组(P<0.05),观察组肝损伤发生率为7.50%低于对照组的肝损伤发生率30.00%(P<0.05)。结论:对接受抗结核药物治疗方案的初治肺结核患者,给予复方甘草酸苷联合治疗,能够明显减少肝损伤发生率,能保护患者肝功能,值得推荐使用。
Objective:To observe the clinical effect of Compound Glycyrrhizin in preventing liver injury caused by antituberculosis drugs.Methods:80 patients with pulmonary tuberculosis and normal liver function diagnosed in our hospital from June 2018 to December 2018 were divided into control group and observation group according to the random number table method,40 cases each.Under the same conditions of antituberculosis methods,the control group was given oral glucuronolactone,the observation group was given oral compound glycyrrhizin capsule to detect liver function,including alt,AST,TBIL,GGT and other indicators,as well as the occurrence of liver injury.Results:After treatment,the indexes of liver function in the observation group were better than those in the control group (P<0.05),and the incidence of liver injury in the observation group was 7.50% lower than that in the control group (30%)(P<0.05).Conclusion:The combination of Compound Glycyrrhizin can significantly reduce the incidence of liver injury and protect the liver function of the patients with primary pulmonary tuberculosis,which is worthy of recommendation.
作者
周玉霞
潘婷
李爽
ZHOU Yu-xia;PAN Ting;LI Shuang(Department of Medicine and Equipment,Kaifeng Infectious Disease Hospital,Kaifeng Henan 475001,China;Department of Hepatology,Zhengzhou No.6 People's Hospital,Zhengzhou Henan 450015,China)
出处
《药品评价》
CAS
2020年第12期37-39,共3页
Drug Evaluation
基金
国家十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题(编号2012ZX10004301-005)
河南省郑州市科技局项目(编号CZSYJJ16008)。
关键词
结核病
抗结核药物
复方甘草酸苷胶囊
肝损伤
Tuberculosis
Antituberculous Drugs
Compound Glycyrrhizin Capsule
Liver Injury
