摘要
目的:在正常老年人、老年阿尔茨海默病(AD)患者及慢性老年精神分裂症(schizophrenia)患者中进行认知功能水平的评估,以及阿尔茨海默病相关的尿神经丝蛋白(AD7c-NTP)的检测,探索尿AD7c-NTP在不同认知功能水平的患者中的临床价值。方法:选择正常老年人、老年阿尔茨海默病(AD)患者及慢性老年精神分裂症患者各30例,分别作为对照组,AD组及S组,以简易精神状态量表(MMSE)评估各组对象的认知功能,检测其尿AD7c-NTP水平,比较三组间认知水平和尿AD7c-NTP值的差异,分析MMSE与尿AD7c-NTP值的相关性。结果:三组认知评估及尿AD7c-NTP水平差异均有统计学意义(P<0.05);患者的认知功能与尿AD7c-NTP水平呈负相关(r=-0.597,P=0.000)。结论:尿AD7c-NTP水平变化与认知功能呈负相关,可考虑作为预测老年人认知水平变化的辅助检测手段。
Objective:In order to explore the clinical value of urinary AD7C-NTP in patients with different levels of cognitive function,evaluate the level of cognitive function in normal elderly,elderly Alzheimerdisease(AD)patients and chronic senile schizophrenia(schizophrenia)patients,as well as the detection of urinary Alzheimerdisease-related neurofilament protein(AD7c-NTP).Method:A total of 30 cases of normal elderly,30 cases of Alzheimer disease(AD)and 30 cases of chronic senile schizophrenia were selected as control group,AD group and S group respectively.The cognitive function of each group was evaluated by MMSE,and the urinary AD7c-NTP level was measured.The difference of cognitive level and urinary AD7c-NTP value among the three groups was compared,and the correlation between MMSE and urinary AD7c-NTP value was also analyzed.Result:There were significant differences in cognitive assessment and urinary AD7c-NTP among the three groups(P<0.05).There was a negative correlation between the level of cognitive function and AD7c-NTP(r=-0.597,P=0.000).Conclusion:The change of AD7c-NTP in urine is negatively correlated with the level of cognitive function.It can be considered as an auxiliary detection method to predict the change of cognitive level in the elderly.
作者
郭少楠
陈明钟
官方萍
陈明森
程文桃
黄炜静
陈元生
GUO Shaonan;CHEN Mingzhong;GUAN Fangping;CHEN Mingsen;CHENG Wentao;HUANG Weijing;CHEN Yuansheng(Fuzhou Neuro-Psychiatric Hospital,Fuzhou 350008,China;不详)
出处
《中外医学研究》
2020年第24期6-11,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
福州市科技计划项目(2018-S-104-1)
福建省科技计划项目(2019D001)
福州市临床重点专科建设项目(201710271)。
