摘要
目的研究白桦树Betula platyphylla树皮的化学成分。方法采用硅胶柱色谱及HPLC等色谱技术进行分离纯化,通过理化性质与波谱数据分析鉴定结构。结果从白桦树皮的二氯甲烷萃取物中分离得到20个单体化合物,分别为3-羰基-24-亚甲基环阿尔廷烷(1)、谷甾酮(2)、3β-乙酰基齐墩果酸(3)、羽扇豆醇(4)、柠黄醇(5)、桦木醛(6)、3β-乙酰氧基-11α,12α-环氧齐墩果烷-13β,28-内酯(7)、齐墩果酸(8)、高根二醇(9)、3-羟基-1,7-双(4-羟基苯基)-庚烷(10)、β-谷甾醇(11)、3β,20-二羟基羽扇豆烷(12)、3β-O-咖啡酸桦木醇酯(13)、柏拉图酸(14)、3β,12α-二羟基-齐墩果酸-13β,28-内酯(15)、30-去甲羽扇豆烷-3β,28-二醇-20-酮(16)、桦木酸(17)、桦木醇(18)、1,7-双(4-羟基苯基)-庚烷-4-烯-3-酮(19)、5-羟基-1,7-双(4-羟基苯基)-庚烷-3-酮(20)。结论化合物1、5、7、14~16为首次从该属植物中分离得到,化合物12为首次从该植物中分离得到。
Objective To study the chemical constituents from the barks of Betula platyphylla. Methods The chemical constituents were isolated by silica gel column chromatography and HPLC, and its structure were identified by their spectral data and physicochemical properties analysis. Results A total of 20 compounds were isolated from B. platyphylla, which were identified as 3-oxo-24-methylenecycloartan(1), sitosterone(2), 3β-acetyl oleanolic acid(3), lupeol(4), citrostadienol(5), betulinaldehyde(6), 3β-acetoxyl-11α,12α-epoxy-oleanan-13β,28-olide(7), oleanolic acid(8), erythrodiol(9), 3-hydroxy-1,7-bis(4′,4″-dihydroxyphenyl)-heptane(10), β-sitosterol(11), 3β,20-dihydroxylupane(12), 3β-O-caffeoyl-betulin(13), platanic acid(14), 3β,12α-dihydroxyoleanan-13β,28-olide(15), 30-norlupane-3β,28-diol-20-one(16), betulinic acid(17), betulin(18), 1,7-bis(4′,4″-dihydroxyphenyl)-hept-4-ene-3-one(19), and 5-hydroxy-1,7-bis(4′,4″-dihydroxyphenyl)-hept-3-one(20). Conclusion Compounds 1, 5, 7, 12, 14-16 are isolated from B. platyphylla for the first time, and compounds 1, 5, 7, 14-16 are isolated from betula genus for the first time.
作者
赵明
赵英楠
李军
时志春
王金兰
王丹
张树军
ZHAO Ming;ZHAO Ying-nan;LI Jun;SHI Zhi-chun;WANG Jin-lan;WANG Dan;ZHANG Shu-jun(College of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China;Heilongjiang Industrial Hemp Processing Technology Innovation Center,Qiqihar 161006,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第16期4117-4123,共7页
Chinese Traditional and Herbal Drugs
基金
黑龙江省属高等学校基本科研业务费项目(YSTSXK201808)
齐齐哈尔大学研究生创新科研项目(YJSCX2019027)。
