摘要
昼夜节律普遍存在于生物体中,主要由生物钟控制,使生命活动表现为近似24 h的振荡周期。越来越多研究表明生物钟与心血管生理功能密切相关,血压、心率、自主神经功能、激素分泌、血管内皮功能以及血管收缩和舒张均受生物钟的调节。临床上,晕厥发作是在上午达到高峰,大多数直立不耐受(OI)患儿血压昼夜节律异常,模拟失重大鼠模型提示心血管节律紊乱,提示OI的发生、发展与昼夜节律关系密切。该文介绍了昼夜节律与OI的关系及其可能机制的研究进展。
Circadian rhythm widely exists in living organism, andit is regulated by the biological clock,which keeps life activities showing a rhythmic oscillation with a period of approximately 24 hours. Growing evidence has shown that circadian rhythms areclosely related to the physiological function of the cardiovascularsystem,and blood pressure,heart rate,hormone secretion,en-dothelial function,vasoconstriction and vasodilation are regulatedby the biological clock. Clinically,syncopal episodes peak in themorning,and abnormal blood pressure circadian pattern exists inmost children with orthostatic intolerance(OI). Simulated mi-crogravity can lead to circadian rhythm disorders in rats’ car-diovascular system. It suggests that circadian rhythms play animportant role in the occurrence and development of OI. Thepaper introduces the relationship between circadian rhythm andOI as well as its possible mechanism.
作者
王成
蔡虹
WANG Cheng;CAI Hong(Department of Pediatric Cardiovasology,Children’s Medical Center,the Second Xiangya Hospital,Cen-tral South University,Changsha 410011,China)
出处
《中国实用儿科杂志》
CSCD
北大核心
2020年第8期588-592,共5页
Chinese Journal of Practical Pediatrics
关键词
生物钟
昼夜节律
直立不耐受
儿童
biological clock
circadian rhythm
orthostatic in-tolerance
child
