摘要
胃癌的全球发病率较高,早期诊断率低,大多数患者初诊时已是晚期,患者5年生存率低。寻找有效的检测方法、提高胃癌的早期诊断率是改善胃癌患者预后的重要手段之一。微RNA(miRNA)通过改变癌基因和抑癌基因的表达在肿瘤发生、发展过程中起重要作用。miRNA在多种肿瘤中表达,血清/血浆、组织中的miRNA以非常稳定的形式存在,被认为是一种新的肿瘤生物标志物,具有良好的临床应用前景。miRNA与胃癌的发生、发展有关,为胃癌的诊断、治疗、随诊提供了新的方法和思路。
The incidence rate of gastric cancer is high,but the early diagnosis rate is low,most patients are at advanced stage at the first diagnosis,and the 5-year survival rate is low.It is one of the important means to improve the prognosis of gastric cancer by finding effective detection methods to improve the early diagnosis rate.MicroRNA(miRNA)plays an important role in tumorigenesis by altering the expression of oncogenes and tumor suppressor genes.miRNA is expressed in a variety of tumors.As the miRNA in serum/plasma and tissues can exist in a very stable form,they are considered as new tumor biomarkers with good clinical application prospects.More and more studies have shown that miRNA is related to the occurrence and development of gastric cancer,which can provide new methods and ideas for the diagnosis,treatment and follow-up.
作者
贾晶莹
本巴吉
韩军
祁玉娟
JIA Jingying;BEN Baji;HAN Jun;QI Yujuan(Graduate School,Qinghai University,Xining 810016,China;Department of Medical Oncology,Qinghai Provincial People′s Hospital,Xining 810003,China)
出处
《医学综述》
2020年第17期3421-3428,共8页
Medical Recapitulate
基金
青海省科技厅自然科学基金课题面上项目(2017-ZJ-907)。
