摘要
目的:探讨乌司他丁与连续性肾脏替代疗法(CRRT)联合治疗多器官功能障碍综合征(MODS)患者总超氧化物歧化酶(T-SOD)、丙二醛(MDA)、总抗氧化能力(T-AOC)水平的影响。方法:2019年1~12月期间于我院接受CRRT治疗的42例MODS患者纳入对照组,收集同期接受乌司他丁联合CRRT治疗43例MODS患者纳入观察组。两组均连续治疗1周,观察两组治疗前后T-SOD、MDA、T-AOC水平,并对两组进行为期1个月的随访,记录两组病死率。结果:治疗后,两组T-SOD、MDA水平均高于治疗前,T-AOC水平均低于治疗前,且观察组T-SOD、MDA水平均高于对照组,T-AOC水平低于对照组;观察组病死率(13.95%)低于对照组(33.33%),差异有统计学意义(P<0.05)。结论:乌司他丁联合CRRT治疗MODS患者可有效改善T-SOD、MDA、T-AOC水平,降低病死率。
Objective:To investigate the effects of ulinastatin combined with continuous renal replacement therapy(CRRT)for the treatment of total superoxide dismutase(T-SOD),malondialdehyde(MDA)and total resistance oxidation capacity(T-AOC)levels in patients with multiple organ dysfunction syndrome(MODS).Methods:42 MODS patients who received CRRT treatment in our hospital from January 2019 to December 2019 were included in the control group.43 MODS patients who received Ulinastatin combined with CRRT treatment in the same period were collected,and included in the observation group.Both groups were treated continuously for 1 week.The levels of T-SOD,MDA and T-AOC before and after treatment were observed,and the two groups were followed up for 1 month,recorded the mortality of the two groups.Results:After treatment,the levels of T-SOD and MDA in the two groups were higher than that before treatment,and the levels of T-AOC were lower than that before treatment,and the levels of T-SOD and MDA in the observation group were higher than the control group,and the levels of T-AOC were lower than the control group.The mortality rate of the observation group(13.95%)was lower than the control group(33.33%),the difference was statistically significant(P<0.05).Conclusion:Ulinastatin combined with CRRT in the treatment of MODS patients can effectively improve the levels of T-SOD,MDA,T-AOC and reduce the mortality.
作者
董翔飞
DONG Xiang-fei(The Second Affiliated Hospital,Henan University of Science and Technology,Henan Luoyang 471000,China)
出处
《中国药物评价》
2020年第4期295-297,共3页
Chinese Journal of Drug Evaluation
