摘要
目的:比较醋酸曲瑞普林、孕三烯酮片及米非司酮片用于子宫内膜异位症(EMT)不孕患者腹腔镜术后妊娠结局。方法:选取2012年5月—2017年7月本院收治的132例EMT伴不孕患者,均实施腹腔镜保守性手术,术后分别给予醋酸曲瑞普林(42例),孕三烯酮片(45例)和米非司酮片(45例),对比分析3组药物治疗后临床疗效、疼痛程度(VAS)、性激素水平、妊娠结局和不良反应。结果:治疗后,总有效率醋酸曲瑞普林最高(97.6%),其次米非司酮(88.9%),孕三烯酮片最低(73.3%);3组性激素(FSH、PRL、E2)水平均下降,LH水平均上升,痛经、性交和盆腔痛VAS分值均下降,且醋酸曲瑞普林组和米非司酮组的FSH、PRL、E2水平低于孕三烯酮组,LH水平高于孕三烯酮组,痛经、性交和盆腔痛VAS分值孕三烯酮组最高(P<0.05)。良好妊娠结局比率最高为醋酸曲瑞普林(90.5%),其次米非司酮(62.2%),孕三烯酮组最低(42.2%);不良反应发生率最低为醋酸曲瑞普林7.1%,其次为米非司酮组33.3%,孕三烯酮组最高为40.0%(均P<0.05)。结论:腹腔镜手术联合醋酸曲瑞普林治疗EMT不孕患者疗效最佳,可提高患者术后受孕机率,妊娠结局更好,不良反应更低。
Objective:To compare the pregnancy outcomes of triptorelin acetate,gestrinone and mifepristone tablets for treating infertile women with endometriosis(EMT).Methods:132 infertility women with EMT were enrolled and had received laparoscopic conservative operation from May 2012 to July 2017.After operation,these women were divided into group A group(42 women treated by triptorelin acetate),group B(45 women treated by 45 gestrinone tablets cases),and group C(45 women treated by mifepristone tablets).The clinical efficacy,pain degree by VAS,sex hormones levels,pregnancy outcomes,and adverse reaction rate were compared among these three groups.Results:After treatment,the total effective rate of women in group A was 97.6%,followed was that(88.9%)of women in group C,and that(73.3%)of women in group B(P<0.05).The levels of FSH,PRL and E2,the dysmenorrheal rate,and sexual intercourse,and VAS score of pelvic pain of women in the three groups had decreased significantly after treatment,but LH level had increased.The levels of FSH,PRL and E2 of women in group A and group C were significant lower than those of women in group B,but the LH level of women in group A and group C was significant higher.The dysmenorrheal rate,the sexual intercourse score,or VAS score of pelvic pain of women in group B was the highest.The rate of good pregnancy outcomes of women in group A was 90.5%,then was that(62.2%)of women in group C,and that(42.2%)of women in group B was the lowest.The incidence of adverse reaction of women in group A was 7.1%,followed by that(33.3%)of women in group C,and then that(40.0%)of women in group B(all P<0.05).Conclusion:Laparoscopic surgery combined with triptorelin acetate for treating infertile women with EMT has the best curative effect,which can improve the pregnancy rate,and has better pregnancy outcomes and less adverse reaction.
作者
王亚莉
周晓莉
刘杰
赵嫦娥
汪黎明
WANG Yali;ZHOU Xiaoli;LIU Jie;ZHAO Changer;WANG Liming(General Hospital of the Central Theater Command, PLA, Wuhan, Hubei Province, 430070;Hubei Maternal and Child Health Care Hospital)
出处
《中国计划生育学杂志》
2020年第8期1185-1189,共5页
Chinese Journal of Family Planning
