摘要
目的:对比分析自拟益肾降浊方汤剂与尿毒清颗粒对慢性肾衰竭患者微炎性状态的影响。方法:将96例慢性肾衰竭患者随机分为益肾降浊组、尿毒清组和对照组,各32例。其中益肾降浊组采用常规治疗结合服用自拟益肾降浊方治疗,尿毒清组采用常规治疗结合服用尿毒清颗粒治疗,对照组仅应用常规治疗,对比分析患者三组患者血清超敏C反应蛋白(High Sensitivity C-reactive Protein,hs-CRP)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、白细胞介素(Interleukin,IL)-6、血肌酐(Serum Crentinine,Scr)和尿素氮(Blood Urea Nitrogen,BUN)水平。结果:益肾降浊组和尿毒清组治疗后hs-CRP、TNF-α和IL-6明显低于治疗前,差异有统计学意义(P<0.05)。三组之间hs-CRP、TNF-α和IL-6之间差异有统计学意义,具体表现在益肾降浊组明显低于尿毒清组,益肾降浊组和尿毒清组明显低于对照组,差异有统计学意义(P<0.05)。益肾降浊组和尿毒清组Scr、BUN和肌酐清除率(Creatinine Clearance Rate,Ccr)与治疗前差异有显著统计学意义(P<0.01),对照组Scr、BUN和Ccr与治疗前差异有显著统计学意义(P<0.05);益肾降浊组和尿毒清组Scr、BUN和Ccr与对照组差异有统计学意义(P<0.05),益肾降浊组Scr、BUN和Ccr与尿毒清组差异有统计学意义(P<0.05)。三组患者治疗后神疲乏力、腰膝酸软和纳少评分与治疗前差异有统计学意义(P<0.05);益肾降浊组神疲乏力、腰膝酸软和纳少评分明显低于尿毒清组和对照组,差异有统计学意义(P<0.05);尿毒清组神疲乏力和腰膝酸软评分明显低于对照组,差异有统计学意义(P<0.05),纳少评分两组差异无统计学意义(P>0.05)。结论:自拟益肾降浊方能够显著降低慢性肾衰竭患者微炎症状态,提高患者肾功能。
Objective:To compare and analyze the effects of the Yishen Jiangzhuo decoction(益肾降浊方)and the Niaoduqing granules(尿毒清颗粒)on micro-inflammatory state in patients with chronic renal failure.Methods:96 patients were randomly divided into the Yishen Jiangzhuo group,Niaoduqing group and control group,32 cases in each.The Yishen Jiangzhuo group was treated with conventional treatment with the Yishen Jiangzhuo prescription,the Niaoduqing group was treated with conventional treatment with the Niaoduqing granules,and the control group was only treated with conventional treatment.Results:The hs-CRP,TNF-αand IL-6 in the Yishen Jiangzhuo group and Niaoduqing group were significantly lower than before treatment(P<0.05).The differences between hs-CRP,TNF-αand IL-6 among the three groups were statistically significant,and those in the Yishen Jiangzhuo group were significantly lower than theNiaoduqing group, and those in the Yishen Jiangzhuo group and the Niaoduqing group were significantly lower than the control group(P<0.05). Scr, BUN and Ccr in the three groups showed significantly differents between before and after treatment (P<0.05). And those inthe Yishen Jiangzhuo group and Niaoduqing group were better than the control group (P<0.05), and those in the Yishen Jiangzhuo groupwere best (P<0.05). The symptom scores in three groups showed differences between before and after treatment (P<0.05). And those in theYishen Jiangzhuo group were least (P<0.05). Scores of general lassitude and soreness of the waist and the knees in the Niaoduqing groupwere significantly lower than the control group (P<0.05), and scores of eat less did not show difference between the Yishen Jiangzhuo groupand Niaoduqing group (P>0.05). Conclusion: The Yishen Jiangzhuo prescription can significantly reduce the micro-inflammatory state inpatients with chronic renal failure and improve the renal function.
出处
《中医临床研究》
2020年第23期56-59,共4页
Clinical Journal Of Chinese Medicine
关键词
益肾降浊方
微炎性
尿毒清颗粒
The Yishen Jiangzhuo prescription
Micro-inflammatory
The Niaoduqing granules
