CRRT对脓毒症合并急性肾损伤患者血清CRP、IL-6、IL-10、KIM-1水平的影响被引量：5

Effect of continuous renal replacement therapy on serum c-reactive protein,interleukin(IL)-6,IL-10 and kindney injury molecule-1(KIM-1)levels among patients with sepsis and infectious acute kidney injury

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摘要目的探究连续性肾脏替代治疗(CRRT)对脓毒症合并急性肾损伤(AKI)患者血清C反应蛋白(CRP)、白介素-6(IL-6)、白介素-10(IL-10)、肾损伤分子-1(KIM-1)的影响。方法根据是否进行CRRT治疗将172例脓毒症合并AKI患者分为CRRT组及非CRRT组,于治疗前及治疗12、24、48 h时测定白细胞计数(WBC)、血肌酐(Scr)、尿素氮(BUN)、CRP、IL-6及KIM-1等指标,比较两组28 d内肾功能恢复率、病死率及住院时间。结果CRRT组治疗12、24、48 h时CRP、IL-6、IL-10水平均低于治疗前及非CRRT组(均P<0.05),非CRRT组治疗48 h时CRP、IL-6、IL-10水平低于治疗前(均P<0.05);CRRT组治疗24、48 h时KIM-1水平低于治疗前及非CRRT组(均P<0.05);CRRT组治疗12、24、48 h时Scr、BUN水平低于治疗前及非CRRT组(均P<0.05),治疗24、48 h时WBC低于治疗前及非CRRT组(均P<0.05);CRRT组28 d内肾功能恢复率高于非CRRT组,28 d内病死率低于非CRRT组,住院时间短于非CRRT组(均P<0.05)。结论 CRRT治疗可降低脓毒症合并AKI患者血清CRP、IL-6、IL-10、KIM-1水平,改善预后。

作者王俊聪袁园 WANG Juncong;YUAN Yuan

机构地区宁波市医疗中心李惠利医院(东部院区)

出处《现代实用医学》 2020年第8期895-897,共3页 Modern Practical Medicine

基金浙江省临床基金项目(ZYC-A61)。

关键词连续性肾脏替代治疗脓毒症急性肾损伤炎症因子肾脏标志物

分类号 R692 [医药卫生—泌尿科学] R459.5 [医药卫生—治疗学]

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