摘要
目的分析探讨3.0 T磁共振伪连续式动脉自旋标记(pseudo-continuous arterial spin labeling,pCASL)技术在脑瘫患儿手术治疗中检测脑血流量变化及评估疗效的应用价值。材料与方法随机选取2017年6月至2019年6月接受颈总动脉外膜交感神经网剥脱术治疗的30例痉挛型单侧脑性瘫痪患儿,设为病例组;选取同期体检健康的30例儿童,设为正常组。应用3.0 T核磁共振仪对正常组儿童与病例组患儿术前、术后14 d进行常规序列、医学影像诊断(diagnostic medical imaging,DMI)、pCASL序列扫描,经后处理工作获得大脑双侧额叶、顶叶、颞叶、中央前回、基底节区等部位脑血流量数据并行统计学分析。结果术前病例组患儿各部位脑血流量较正常组儿童明显降低,差异存在统计学意义(P<0.05);术后14 d病例组患儿各部位脑血流量均得到不同程度改善,其中大脑双侧额叶、颞叶、中央前回、丘脑及小脑区域血流量与正常组比较差异有统计学意义(P<0.05),顶叶、基底节区和内囊区域血流量与正常组比较差异无统计学意义(P>0.05);比较病例组患儿手术前后各部位脑血流量变化情况,除小脑外其余各部位差异均有明显统计学意义(P<0.05)。结论3.0 T MRI pCASL技术可准确地检测出脑瘫患儿各部位脑血流量,反映大脑缺血缺氧状态改善情况,在颈总动脉外膜交感神经网剥脱术疗效评估中有较高的应用价值。
Objective:To explore the application value of 3.0 T pseudo-continuous arterial spin labeling(pCASL)in detecting cerebral blood flow changes and evaluating the efficacy in children with cerebral palsy.Materials and Methods:Thirty children with spasmotic unilateral cerebral palsy who were treated with common carotid artery sympathetic network exfoliation in our hospital from June 2017 to June 2019 were randomly selected as the case group.Thirty healthy children were selected as the normal group.Routine sequence,diagnostic medical imaging(DMI)and pCASL sequences were scanned by 3.0 T MRI on preoperative and 14 d after operation in children of normal group and case group.Data of cerebral blood flow in bilateral frontal lobe,parietal lobe,temporal lobe,central anterior gyrus,basal ganglia and other parts of the brain were obtained through post-processing and statistical analysis.Results:The cerebral blood flow in all parts of the preoperative case group was significantly lower than that of the normal group,and the difference was statistically significant(P<0.05).Each part of the 14 d postoperative cases with cerebral blood flow were improved to varying degrees,among them,the blood flow of the bilateral frontal lobe,temporal lobe,central anterior gyrus,thalamus and cerebellum area of the brain was significantly different from the normal group(P<0.05),parietal lobe and basal ganglia region and internal capsule regional blood flow had no statistically significant difference compared with normal group(P>0.05);the changes of cerebral blood flow before and after the operation were compared among the patients in the case group,and the differences were statistically significant except for the cerebellum(P<0.05).Conclusions:3.0 T MRI pCASL technique can accurately detect cerebral blood flow in various parts of cerebral palsy children,reflecting the improvement of cerebral ischemia and hypoxia,and has a high application value in the evaluation of the efficacy of common carotid artery adventitia sympathetic network stripping.
作者
王禄伟
杜金骏
韩秉艳
WANG Luwei;DU Jinjun;HAN Bingyan(Department of Radiology,the Second Affiliated Hospital of Xinjiang Medical University,Urumchi 830028,China)
出处
《磁共振成像》
CAS
2020年第9期726-729,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
新疆维吾尔自治区自然科学基金(基金编号:2019D01C233)。
关键词
脑性瘫痪
磁共振成像
伪连续式动脉自旋标记技术
脑血流量
cerebral palsy
magnetic resonance imaging
pseudo-continuous arterial spin labeling
cerebral blood flow
