摘要
目的探讨北京市通州区老年居民甲状腺结节患病情况及影响因素分析。方法采取整群抽样的横断面研究方法,选取北京市通州城区永顺地区2017年6—12月60岁及以上的常驻居民3639例进行体检,采用统一设计的调查问卷,对受检者的基本信息、既往病史进行调查,所有志愿者统一接受甲状腺B超检查,并根据B超结果分为结节组和非结节组,对比两组受检者的血压、体质指数、三酰甘油、总胆固醇、空腹血糖、甲状腺过氧化物酶抗体、尿碘等方面的差异,分析甲状腺结节发生的相关因素。结果共纳入3639例老年居民,甲状腺结节的患病率为49.68%(1808/3639)。单因素分析结果显示,结节组与非结节组在年龄、性别、收缩压、体质指数、尿素氮、尿酸、天冬氨酸氨基转移酶、三酰甘油、促甲状腺激素、癌胚抗原方面的差异有统计学意义(均P<0.05)。多因素Logistic回归分析结果显示,女性(OR=1.577,95%CI:1.358~1.832)、年龄大(OR=1.025,95%CI:1.012~1.038)、体质指数高(OR=1.032,95%CI:1.013~1.052)是患甲状腺结节的危险因素,尿素氮(OR=0.945,95%CI:0.902~0.990)、促甲状腺激素(OR=0.925,95%CI:0.882~0.970)、癌胚抗原(OR=0.967,95%CI:0.941~0.994)水平的升高是甲状腺素结节患病风险的保护因素。结论女性、肥胖是老年人甲状腺结节患病的危险因素;促甲状腺激素、尿素氮、癌胚抗原的升高可能是其独有的保护因素。
Objective To investigate the prevalence and its related factors of thyroid nodules in elderly residents in Tongzhou District of Beijing.Methods This is a cross-sectional study with cluster sampling.A total of 3639 elderly volunteers aged 60 years and over receiving annual multiphasic health checkups were enrolled in Yongshun,Tongzhou District of Beijing from June to December 2017.A uniformly designed questionnaire was used 10 investigale the subject s basic information and previous medical history.All volunteers received a B ultrasound examination of the thyroid gland,and were divided into the nodular group and non nodular group based on the results of the B-ultrasound.The differences between the two groups in blood pressure.body mass index.triglycerides,total cholesterol,fasting blood glucose.thyroid peroxidase antibodies,urine iodine and other indicators were compared so as to analyze the risk factors for thyroid nodules.Results A total of 3639 elderly residents were included.The prevalence of thyroid nodules was 49.68%(1808/3639).Univariate analysis showed that there were significant differences between nodule group and non-nodule group in the age.gender.systolie blood pressure.body mass index.urea nitrogen.urie acid.aspartate aminotransferase,triglycerides,thyroid stimulating hormone and carcinoembryonic antigen(P<0.05).Multivariate Logistic regression analysis showed that women(OR=1.577.95%CI:1.358-1.832),age(OR=1.025.95%CI:1.012-1.038),body mass index(OR=1.032.95%CI:1.013-1.052)were risk factors for thyroid nodules.Inereasing levels of urea nitrogen(OR=0.945.95%CI;0.902-0.990).thyroid stimulating hormone(OR=0.925,95%CI;0.882-0.970)and carcinoembryonic antigen(OR=0.967,95%CI:0.941-0.994)were protective factors for thyroid nodules.Conclusions Women and obesity are risk factors for thyroid nodules and increasing levels of thyroid stimulating hormone,urea nitrogen and carcinoembryonic antigen may be unique protective factors for thyroid nodules in the elderly.
作者
王岚峰
王旭红
Wang Lanfeng;Wang Xuhong(Metabolism and Im mune Diseases Center,Luhe Hospital,Capital Medical University,Beijing 101149,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2020年第9期1077-1081,共5页
Chinese Journal of Geriatrics
