摘要
目的探讨甲状腺功能正常的甲状腺结节发生与年龄、性别、饮食习惯及甲状腺相关激素之间的关系。方法回顾性分析2012年2月至2018年11月北京市石景山医院进行甲状腺结节筛查的2454名体检人群的资料,对所有入组的资料进行归类汇总,分析可能影响甲状腺结节发生的因素。结果2454名体检人群中检出甲状腺结节患者909例,检出率为37.04%(909/2454),其中男性检出率为32.87%(164/499),女性检出率为38.11%(745/1955),女性检出率显著高于男性(χ^2=4.684,P=0.030)。多因素Logistic回归分析显示性别(OR=0.608,95%CI 0.0471~0.784)、年龄(OR=0.944,95%CI 0.935~0.953)、碘盐摄入(OR=0.646,95%CI 0.447~0.934)、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)(OR=1.562,95%CI 1.374~1.775)、游离甲状腺素(free thyroxine,FT4)(OR=0.924,95%CI 0.889~0.960)、促甲状腺激素(thyroid stimulating hormone,TSH)(OR=1.111,95%CI 1.059~1.167),均为影响甲状腺结节发生的独立危险因素(P均<0.05)。而海产品的摄入(OR=0.867,95%CI 0.674~1.115,P=0.266)不是甲状腺结节发生的独立危险因素。结论甲状腺结节的发生与多种因素密切相关,其中性别、年龄、碘盐摄入、FT3、FT4与TSH是影响甲状腺结节发生的独立危险因素。
Objective To explore the relationship between the occurrence of thyroid nodules with normal thyroid function and age,sex,diet and thyroid related hormones.Methods From February 2012 to November 2018,the data of 2454 people who had thyroid nodule screening in Shijingshan Hospital of Beijing were analyzed retrospectively.All the data were classified and summarized to analyze the factors that may affect the occurrence of thyroid nodule.Results In all 2454 patients,909 patients with Thyroid nodule were detected,the detection rate was 37.04%(909/2454),the detection rate was 32.87%(164/499)in males and 38.11%(745/1955)in females,which was significantly higher than that in males(χ^2=4.684,P=0.030).Multivariate Logistic regression analysis showed that gender(OR 0.608,95%P 0.0471-0.784),age(OR 0.944,95%CI 0.935-0.953),iodized salt intake(OR 0.646,95%CI 0.447-0.934),free triiodothyronine(FT)3(OR 1.562,95%CI 1.374-1.775),free thyroxine(FT)4(OR 0.924,95%CI 0.889-0.960),thyroid stimulating hormone(TSH)(OR 1.111,95%CI 1.059-1.167)(all P<0.05),were thyroid nodules independent risk factors of thyroid nodule.The seafood intake(OR 0.867,95%P 0.674-1.115,P=0.266)is not anindependent risk factor for thyroid nodules occur.Conclusion The occurrence of thyroid nodule is closely related to many factors,among which gender,age,iodized salt intake,FT3,FT4 and TSH are the independent risk factors.
作者
李彦娟
王磊
王钰
张丽
冯京华
Li Yanjuan;Wang Lei;Wang Yu;Zhang Li;Feng Jinghua(Department of Ultrasound,Shijingshan Teaching Hospital of Capital Medical University&Shijingshan Hospital,Beijing 100043,China;Department of Nuclear Medicine,Shijingshan Teaching Hospital of Capital Medical University&Shijingshan Hospital,Beijing 100043,China;Department of Medical Imaging,Beijing North Hospital of Ordnance Industry,Beijing 100089,China)
出处
《中国综合临床》
2020年第5期455-459,共5页
Clinical Medicine of China
关键词
甲状腺结节
超声检查
筛查
回归分析
Thyroid nodules
Ultrasonography
Screening
Regression analysis
