摘要
目的探究噻托溴铵吸入联合糖皮质激素治疗慢性阻塞性肺气肿的临床效果。方法依据就诊的先后循序将2017年10月~2019年8月我院收治的94例慢性阻塞性肺气肿患者随机分为观察组和对照组,每组各47例,观察组患者进行噻托溴铵吸入联合糖皮质激素治疗,对照组患者单纯进行噻托溴铵吸入治疗,比较两组患者药物治疗总有效率、治疗前后肺功能指标改善情况、血气指标及6 min步行距离(6MWD)和用药不良反应总发生率。结果观察组患者治疗总有效率为93.62%,高于对照组的76.60%,差异有统计学意义(P<0.05)。治疗后,两组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、(FEV1/FVC)及最大通气量(MVV)水平均高于本组治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的FVC、FEV1、FEV1/FVC及MVV水平均高于对照组,差异有统计学意义(P<0.05)。观察组患者血氧分压(PaO2)高于对照组,血二氧化碳分压(PaCO2)低于对照组,6MWD长于对照组,差异有统计学意义(P<0.05);观察组患者用药不良反应总发生率为8.51%,低于对照组的23.40%,差异有统计学意义(P<0.05)。结论噻托溴铵吸入联合糖皮质激素治疗慢性阻塞性肺气肿,能够提高患者的临床治疗有效率,改善患者肺功能及血气指标,提高患者的运动耐量,还能降低药物不良反应发生率。
Objective To explore the clinical effect of Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema.Methods According to the order of visits,94 patients with chronic obstructive pulmonary emphysema admitted to our hospital from October 2017 to August 2019 were randomly divided into observation group and control group,47 cases in each group.The observation group were treated with Tiotropium Bromide Inhalation combined with Glucocorticoid,and the control group were treated with Tiotropium Bromide Inhalation only.The total effective rate of drug treatment,the improvement of pulmonary function indicators before and after treatment,blood gas indicators,6-minute walking distance(6MWD)and the total incidence of drug adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.62%,which was higher than that in the control group of 76.60%,the difference was statistically significant(P<0.05).After treatment,the levels of forced vital capacity(FVC),forced expiraton volumone second(FEV1),FEV1/FVC and maximum ventilation(MVV)of patients of the two groups were higher than those of the group before treatment,the differences were statistically significant(P<0.05);the FVC,FEV1,FEV1/FVC and MVV levels of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).The partial pressure of blood oxygen(PaO2)of the observation group was higher than that of the control group,the partial pressure of blood carbon dioxide(PaCO2)was lower than that of the control group,and the 6MWD was longer than that of the control group,the differences were statistically significant(P<0.05).The total incidence of drug adverse reactions in the observation group was 8.51%,which was lower than that in the control group of 23.40%,the difference was statistically significant(P<0.05).Conclusion Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema can improve the clinical treatment efficiency of patients,improve the pulmonary function and blood gas indicators of patients,improve the exercise tolerance of patients,and reduce the incidence of drug adverse reactions.
作者
赵楠
ZHAO Nan(The First Department of Respiratory Medicine,Iron Coal General Hospital of Liaoning Health Industry Group,Liaoning Province,Diaobingshan 112700,China)
出处
《中国当代医药》
2020年第25期37-39,43,共4页
China Modern Medicine
关键词
噻托溴铵吸入
糖皮质激素
慢性阻塞性肺气肿
临床应用
Tiotropium Bromide Inhalation
Glucocorticoids
Chronic obstructive pulmonary emphysema
Clinical application
