摘要
目的观察营养干预对地中海贫血(地贫)患儿营养状况和生长发育的影响。方法将110例地贫患儿随机分为干预组59例和对照组51例。两组患儿均给予膳食指导,干预组加服地贫营养包,疗程均为6个月。观察干预前后两组患儿生长迟缓、低体质量和消瘦的发生率及体质量、儿科营养不良量表(STAMP)评分,以及红细胞计数、血红蛋白、血清总蛋白、血清白蛋白和25-羟基维生素D[25-(OH)D]的水平。结果干预后,干预组的生长迟缓率、低体质量率、消瘦率、STAMP评分均低于干预前,且生长迟缓率、低体质量率、STAMP评分均低于对照组,而体质量大于干预前(均P<0.05);干预组患儿的红细胞计数、血红蛋白、血清白蛋白、25-(OH)D水平高于干预前及对照组(均P<0.05)。结论营养干预可有效地改善地贫患儿的营养状况,促进生长发育。
Objective To observe the effect of nutritional intervention on the nutritional status and growth and development of children with thalassemia.Methods A total of 110 children with thalassemia were randomly divided into intervention group(n=59)and control group(n=51).Both groups were given dietary guidance,the intervention group received additional nutrition package for thalassemia prevention,and the treatment lasted for six months in both groups.The indices were observed in the two groups before and after intervention,including incidence rates of growth retardation,low body mass and marasmus,body mass,the Screening Tool for the Assessment of Malnutrition in Pediatrics(STAMP)score,and the levels of RBC count,hemoglobin,serum total protein,serum albumin and 25-hydroxyvitamin D[25-(OH)D].Results After intervention,the intervention group had lower rates of growth retardation,low body mass and marasmus,and lower STAMP score than the pre-intervention,exhibited lower rates of growth retardation and low body mass,and lower STAMP score than the control group,along with greater body mass than the pre-intervention(all P<0.05);the intervention group obtained higher levels of RBC count,hemoglobin,serum albumin and 25-(OH)D than the pre-intervention and the control group(all P<0.05).Conclusion Nutritional intervention can significantly improve nutritional status of thalassemia children,promoting growth and development.
作者
黄玲
谢琪
杨潍嘉
吴霖浦
符煜
王雁
HUANG Ling;XIE Qi;YANG Wei-jia;WU Lin-pu;FU Yu;WANG Yan(Department of Nutriology,Guilin People′s Hospital,Guilin 541001,China)
出处
《广西医学》
CAS
2020年第16期2084-2087,共4页
Guangxi Medical Journal
基金
广西医药卫生科研课题(Z2016699)。
关键词
地中海贫血
营养干预
生长发育
儿童
Thalassemia
Nutritional intervention
Growth and development
Children
