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猴头菌提取物颗粒联合三联疗法对小儿幽门螺杆菌相关性胃病的疗效和安全性 被引量:6

Efficacy and safety of Hericium erinaceus extract granules combined with triple therapy on Helicobacter pylori-related gastropathy in children
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摘要 目的分析猴头菌提取物颗粒联合三联疗法对小儿幽门螺杆菌(Hp)相关性胃病的疗效和安全性。方法回顾性选取2017年1月至2019年3月菏泽市中医医院收治的98例Hp相关性胃病患儿,根据治疗方案不同将患儿分为两组,每组各49例。对照组患儿予以三联疗法,观察组患儿予以猴头菌提取物颗粒联合三联疗法。对比两组患儿的临床疗效、Hp根除率、不良反应情况、复发情况及治疗前后症状改善、营养状态[白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)及铁蛋白(SF)]、免疫功能(CD8^+、CD3^+、CD4^+/CD8^+)。结果 (1)临床疗效、Hp根除率:观察组患儿的总有效率(95.92%)、Hp根除率(91.84%)高于对照组(83.67%、63.27%),差异具有统计学意义(P<0.05);(2)症状改善情况:治疗2个疗程后,观察组患儿的嗳气(0.87±0.15)分、反酸(0.74±0.32)分、胀气(0.69±0.18)分及上腹部疼痛(1.05±0.49)分评分低于对照组(1.49±0.27)分、(1.02±0.41)分、(0.95±0.29)分、(1.63±0.54)分,差异具有统计学意义(P<0.05);(3)营养状态:治疗2个疗程后,观察组患儿的血浆ALB(39.19±3.97) g/L、PA(294.32±25.07) mg/L、Hb(129.38±34.21) g/L、SF(38.30±4.30)μg/L水平高于对照组(37.01±4.84) g/L、(267.41±23.58) mg/L、(110.85±39.74) g/L、(31.45±3.79)μg/L,差异具有统计学意义(P<0.05);(4)免疫功能:治疗2个疗程后,观察组患儿的CD8^+(20.45±2.64)%水平低于对照组,CD3^+(69.09±7.31)%、CD4^+/CD8^+(1.60±0.31)水平高于对照组(23.76±3.36)%、(65.12±8.44)%、CD4^+/CD8^+(1.35±0.42),差异具有统计学意义(P<0.05);(5)不良反应:两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05);(6)复发率:治疗3、6个月后,观察组患儿的复发率(2.33%、6.98%)低于对照组(22.22%、29.63%),差异具有统计学意义(P<0.05)。结论猴头菌提取物颗粒联合三联疗法治疗小儿Hp相关性胃病,疗效确切,能有效提高Hp根除率,缓解症状,改善营养状态,调节细胞免疫功能,降低复发率。 Objective To analyze the efficacy and safety of Hericium erinaceus extract granules combined with triple therapy on pediatric Helicobacter pylori (Hp)-related gastropathy.Methods 98 cases of pediatric Hp-related gastropathy in Heze Hospital of Traditional Chinese Medicine from January 2017 to March 2019 were selected in this retrospective study and they were divided into two groups according to the treatment methods,with 49 cases in each group.The control group were treated with triple therapy,and the observation group were treated with Hericium erinaceus extract granules combined with triple therapy.The clinical efficacy,HP eradication rate,the incidence of adverse reactions,recurrence rate,symptom improvement before and after treatment,nutritional status[albumin (ALB),prealbumin (PA),hemoglobin (Hb),and ferritin (SF)],immune function (CD8^+,CD3^+,CD4^+/CD8^+) were compared between the two groups.Results (1) Clinical efficacy and HP eradication rate:The total effective rate (95.92%) and HP eradication rate (91.84%) of the children in the observation group were higher than those in the control group (83.67%,63.27%),the differences were statistically significant (P<0.05);(2) Symptom improvement:After two courses of treatment,the scores of belching (0.87±0.15) points,acid reflux (0.74±0.32) points,flatulence (0.69±0.18) points,and upper abdominal pain (1.05±0.49) points of the children in the observation group were lower than those of the control group[(1.49±0.27)points,(1.02±0.41) points,(0.95±0.29) points,(1.63±0.54) points],the differences were statistically significant (P<0.05);(3) Nutrition status:After two courses of treatment,the level of plasma ALB (39.19±3.97) g/L,PA (294.32±25.07) mg/L,Hb (129.38±34.21) g/L,and SF (38.30±4.30)μg/L of the children in the observation group were higher than those in the control group[(37.01±4.84)g/L,(267.41±23.58) mg/L,(110.85±39.74) g/L,(31.45±3.79)μg/L],the differences were statistically significant (P<0.05);(4)Immune function:After two courses of treatment,the levels of CD8^+(20.45±2.64)%in the observation group were lower than that in the control group (23.76±3.36)%,and the levels of CD3^+(69.09±7.31)%and CD4^+/CD8^+(1.60±0.31) were higher than those in the control group[(65.12±8.44)%,CD4^+/CD8^+],the differences were statistically significant (P<0.05);(5) Adverse reactions:There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05);(6) Recurrence rate:After three and six months of treatment,the recurrence rate of children in the observation group (2.33%,6.98%) was lower than those in the control group (22.22%,29.63%),and the differences were statistically significant (P<0.05).Conclusion The combined therapy of Hericium erinaceus extract granules and triple therapy is effective in treatment of Hp related gastropathy in children,it can effectively improve the eradication rate of Hp,relieve symptoms,improve nutritional status,regulate cellular immune function,and reduce the recurrence rate.
作者 蔡东兰 CAI Dong-lan(Department of Spleen and Stomach Diseases,Heze Hospital of Traditional Chinese Medicine,Heze Shandong 274000,China)
出处 《临床和实验医学杂志》 2020年第17期1848-1851,共4页 Journal of Clinical and Experimental Medicine
基金 山东省卫生厅基金(编号:2018HZ806)。
关键词 幽门螺杆菌 胃病 猴头菌提取物颗粒 三联疗法 营养状态 免疫功能 Helicobacter pylori Hericium erinaceus extract granules Triple therapy Gastropathy Nutritional status Immune function
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