摘要
目的探讨百令胶囊联合辛伐他汀对2型糖尿病肾病患者氧化与抗氧化失衡及炎性介质水平的影响。方法回顾性分析2017年2月—2018年9月2型糖尿病肾病患者90例的临床资料,根据治疗方式分为A组和B组,每组45例。B组给予辛伐他汀治疗,A组在B组基础上加用百令胶囊治疗。比较2组的临床疗效、尿素氮(BUN)、血肌酐(Scr)、血清胱抑素C(Cys C)、超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、活性氧(ROS)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及不良反应发生情况。结果A组临床治疗总有效率高于B组(P<0.05)。治疗后,2组Cys C、Scr、BUN、hs-CRP、IL-6、TNF-α、MDA水平和ROS活性较治疗前降低,A组低于B组(P<0.05)。治疗后,2组SOD水平和GSH-Px活性较治疗前升高,且A组高于B组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论百令胶囊联合辛伐他汀可提高2型糖尿病肾病患者肾功能,调节体内氧化与抗氧化平衡,降低炎性介质水平,且安全性较高。
Objective To investigate the effects of Bailing capsule combined with Simvastatin on oxidation and anti-oxidation imbalance and inflammatory mediators levels in patients with type 2 diabetic nephropathy(T2DN).Methods The clinical data of 90 patients with T2DN from February 2017 to September 2018 were retrospectively analyzed.According to the treatment methods,they were divided into group A and group B,with 45 cases in each group.Group B was treated with Simvastatin,and group A was treated with Bailing capsule on the basis of group B.The clinical efficacy,urea nitrogen(BUN),serum creatinine(Scr),cystatin C(Cys C),superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),reactive oxygen species(ROS),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in group A was higher than that in group B(P<0.05).After treatment,the levels of Cys C,Scr,BUN,hs-CRP,IL-6,TNF-α,MDA and ROS activity in the two groups were lower than those before treatment,and those were lower in group A than in group B(P<0.05).After treatment,SOD level and GSH-Px activity in both groups were higher than those before treatment,and the indexes were higher in group A than in group B(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Bailing capsule combined with Simvastatin can improve renal function levels of patients with T2DN,regulate oxidation and anti-oxidation balance in the body,and reduce levels of inflammatory mediators,with relatively higher safety.
作者
王东春
肖红
舒琴
闵凡
朱万胜
WANG Dong-chun;XIAO Hong;SHU Qin;MIN Fan;ZHU Wan-sheng(Department of Pharmacy,the Second People's Hospital of Neijiang,Neijiang,Sichuan 641000,China)
出处
《解放军医药杂志》
CAS
2020年第9期39-43,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
四川省卫生和计划生育科研项目(18PJ109)。
关键词
糖尿病肾病
糖尿病
2型
辛伐他汀
百令胶囊
超氧化物歧化酶
白介素-6
Diabetic nephropathies
Diabetes mellitus,type 2
Simvastatin
Bailing capsule
Superoxide dismutase
Interleukin-6
