摘要
背景:环状RNA是近年来表观遗传学领域最受关注的明星分子,已证实具有普遍性、进化保守性、结构稳定性、组织特异性和功能多样性等特征。随着骨关节炎基础研究逐步深入,多种机制被揭示,环状RNA在其中起重要作用。目的:归纳整理了环状RNA在骨关节炎研究中的进展,综述其在骨关节炎症调控、软骨细胞的衰老凋亡、细胞外基质成分改变以及机械应力刺激等病理机制中的作用。方法:第一作者应用计算机检索PubMed数据库、Web of Science和Medline等数据库,英文检索词"circular RNA,osteoarthritis,cartilage,chondrocyte",检索时间为2015年3月至2020年3月。结果与结论:①环状RNA是骨关节炎发生、发展的重要环节,能够作为诊断标志物和生物治疗靶点;②此外,当前的研究仅局限于环状RNA作为吸附海绵、关节软骨退变和修复方面,而环状RNA的其他功能机制以及其在间充质干细胞成软骨分化中的研究仍然是未知,这也许是未来基础研究转化为临床成果的方向。
BACKGROUND: Circular RNA is the most concerned star molecules in the field of epigenetics in recent years, and has been proven to have such characteristics as universality, evolutionary conservatism, structural stability, tissue specificity and functional diversity. With the development of basic research on osteoarthritis, various kinds of mechanisms have been revealed, in which circular RNAs play an important role.OBJECTIVE: To summarize the progress of circular RNAs in the research of osteoarthritis, including the regulation of inflammation, the senescence and apoptosis of chondrocytes, the change of extracellular matrix components and the mediation of mechanical stress stimulation.METHODS: The first author used computers to retrieve PubMed, Web of Science, and Medline. English retrieval words were "circular RNA, osteoarthritis, cartilage, chondrocyte". The retrieval period was from March 2015 to March 2020.RESULTS AND CONCLUSION:(1) It is suggested that circular RNA is a pivotal link in the occurrence and progression of osteoarthritis, and can be used as diagnostic markers and biological therapeutic targets.(2) In addition, current studies are limited to circular RNA sponging, articular cartilage degeneration and repair, while other functional mechanisms and the chondrogenic differentiation in mesenchymal stem cells are still unknown. These may be the direction in which basic research will translate into clinical outcomes in the future.
作者
许逸洋
毛谷平
张紫机
康焱
Xu Yiyang;Mao Guping;Zhang Ziji;Kang Yan(Department of Joint Surgery,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China;Provincial School of Clinical Medicine of Fujian Medical University/Second Department of Orthopedics of Fujian Provincial Hospital,Fuzhou 350001,Fujian Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第10期1592-1598,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助项目(81972051),课题名称:利用单细胞测序技术探讨miR-92a-3p对骨髓干细胞向软骨细胞分化过程影响的机制研究,项目负责人:康焱。
