摘要
目的分析糖尿病伴抑郁焦虑患者应用度洛西汀联合二甲双胍治疗后效果。方法将2017年6月~2018年12月期间来我院就诊的91例糖尿病伴抑郁焦虑患者,依据随机数字表法分为对照组45例及观察组46例,两组患者均给予二甲双胍口服及心理干预,在此基础上,对照组患者增加文拉法辛口服治疗,观察组患者增加度洛西汀口服治疗,观察两组患者治疗后神经递质、认知功能、血浆脑源性神经营养因子、炎性因子、焦虑抑郁情绪、皮质醇水平变化,并对比不良反应发生率。结果观察组NE、5-HT、BDNF、NGF水平及WMS各项评分高于对照组,TNF-α、皮质醇、IL-6水平及SDS、SAS评分低于对照组(P<0.05),TESS评分与对照组无统计学意义(P>0.05)。结论度洛西汀能够有效改善糖尿病合并焦虑抑郁患者认知功能,缓解焦虑抑郁情绪,安全性高,其机制与调节神经递质、神经营养因子、皮质醇水平,抑制炎症反应有关。
Objective To analyze the effect of duloxetine combined with metformin in diabetes patients with depression and anxiety. Methods 91 diabetes patients with depression and anxiety who came to our hospital from June 2017 to December 2018 were divided into 45 patients in the control group and 46 patients in the observation group according to the random number table. All the patients were given metformin orally and psychological intervention,the control group patients increased the oral treatment of venlafaxine,the observation group patients increased the dose of duloxetine oral treatment. The neurotransmitter,cognitive function,plasma brain-derived nerve Nutritional factors,inflammatory factors,negative emotions of anxiety and depression,changes in cortisol levels,and the incidence of adverse reactions were observed in two groups of patients before and after treatment. Results The levels of NE,5-HT,BDNF,NGF and WMS in the observation group were higher than those in the control group. The levels of TNF-α,cortisol,IL-6 and SDS and SAS were lower than those in the control group(P<0.05). There was no significant difference in the TESS scores between two group(P>0.05). Conclusion Duloxetine can effectively improve the cognitive function of patients with diabetes and anxiety and depression,relieve anxiety and depression with high safety. The mechanism maybe be related to the regulation of neurotransmitters,neurotrophic factors,cortisol levels and inhibition of inflammatory response.
作者
沈莺
崔桂梅
张娜
刘娟
SHEN Ying;CUI Guimei;ZHANG Na(Department of Diabetes,Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,China)
出处
《国际精神病学杂志》
2020年第4期757-759,771,共4页
Journal Of International Psychiatry
