摘要
目的探讨甲状腺癌患者血清25-羟基维生素D[25(OH)D]水平的变化,及其与血清甲状腺功能指标和甲状腺癌发生风险的相关性。方法选取甲状腺癌患者56例(甲状腺癌组)和甲状腺良性结节患者69例(良性结节组),检测其血清25(OH)D、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白(Tg)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TgAb)水平。根据25(OH)D水平将所有研究对象分为≤20 ng/mL(维生素D缺乏)、>20~≤30 ng/mL(维生素D不足)和>30 ng/mL(维生素D充足)3组。采用Spearman相关分析评估各项指标之间的相关性。采用比值比(OR)及95%可信区间(CI)评估甲状腺癌发生的风险。结果甲状腺癌组血清25(OH)D水平均低于良性结节组(P<0.01),血清TSH水平高于良性结节组(P<0.05)。其他指标2个组之间差异均无统计学意义(P>0.05)。甲状腺癌组25(OH)D与TSH、TPOAb均呈负相关(r值分别为-0.750、-0.872,P<0.01),与FT3、FT4、Tg和TgAb水平均无相关性(r值分别为0.104、0.03、-0.134和-0.149,P>0.05)。25(OH)D≤20 ng/mL时甲状腺癌的发生风险明显升高(OR=7.990,95%CI为1.640~38.100)。结论25(OH)D水平与甲状腺癌发生有关,低25(OH)D水平可能会增加甲状腺癌发生的风险。
Objective To investigate the changes of serum 25-hydroxyvitamin D[25(OH)D]levels in patients with thyroid cancer and the correlation with serum thyroid function indicators and the risk of thyroid cancer.Methods A total of 56 patients with thyroid cancer(thyroid cancer group)and 69 patients with benign thyroid nodules(benign nodule group)were enrolled.Serum 25(OH)D,free triiodothyronine(FT3)and free thyroxine(FT4),thyroid-stimulating hormone(TSH),thyroglobulin(Tg),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)levels were determined.According to the level of 25(OH)D,all the subjects were classified into 3 groups,including vitamin D deficiency(≤20 ng/mL),vitamin D insufficiency(>20-≤30 ng/mL)and vitamin D sufficiency(>30 ng/mL)groups.Spearman correlation analysis was used to evaluate the correlation among various indicators.Odds ratio(OR)and 95%confidence interval(CI)were used to evaluate the risk of thyroid cancer.Results Serum level of 25(OH)D in thyroid cancer group was lower than that in benign nodule group(P<0.01),and serum TSH level was higher(P<0.05).There was no statistical significance in the other indicators between the 2 groups(P>0.05).In thyroid cancer group,25(OH)D was negatively correlated with TSH and TPOAb(r=-0.750 and-0.872,respectively,P<0.01),and it had no correlation with FT3,FT4,Tg and TgAb levels(r=0.104,0.03,-0.134 and-0.149,respectively,P>0.05).The risk of thyroid cancer was increased when 25(OH)D≤20 ng/mL(OR=7.990,95%CI 1.640-38.100).Conclusions 25(OH)D levels are correlated with thyroid cancer,and low 25(OH)D level may increase the risk of thyroid cancer.
作者
陈刚
王晶
邓蔷
陈曦
胡冬
庄利东
CHEN Gang;WANG Jing;DENG Qiang;CHEN Xi;HU Dong;ZHUANG Lidong(Department of Clinical Laboratory,Mianyang Central Hospital,Mianyang 621000,Sichuan,China)
出处
《检验医学》
CAS
2020年第9期885-888,共4页
Laboratory Medicine
