摘要
目的研究温阳化浊方对反复种植失败(RIF)患者冻融胚胎移植(FET)周期妊娠结局的影响。方法93例均为2018年4月—2019年8月期间就诊于天津中医药大学第一附属医院生殖中心的脾肾阳虚湿浊内蕴证RIF患者,按是否行温阳化浊方中医治疗进行分组。其中治疗组52例(自然妊娠5例,实际进入FET周期47例),对照组41例。治疗组于冻融胚胎移植前1~3个月至移植后14天予温阳化浊方治疗,对照组不予任何干预,两组患者均于上次移植失败后3~6个月内行再次FET。比较两组FET子宫内膜容受性相关指标以及移植后12周内妊娠结局。结果治疗组服用中药期间,5例自然妊娠;行FET的患者中临床妊娠率、持续妊娠率、子宫内膜厚度两组比较,差异均有统计学意义(P<0.05);早期流产率、子宫内膜形态及子宫内膜血流两组比较,差异无统计学意义(P>0.05)。结论温阳化浊方可改善RIF患者子宫内膜厚度,提高其临床妊娠率及持续妊娠率。
Objective To observe the effect of Wenyang Huazhuo Compound(WYHZC)on pregnancy outcomes of frozen-thawed embryo transfer(FET)in patients with repeated implantation failure(RIF).Methods A retrospective analysis was performed in RIF patients with Pi-Shen yang deficiency and dampness accumulation syndrome(PSYD-DAS)treated in Reproduction Center,First Teaching Hospital,Tianjin University of Traditional Chinese Medicine from April 2018 to August 2019.RIF patients with PSYD-DAS were recruited as the treatment group(52 cases including 5 with natural pregnancy and 47 with actual entry into FET c y c le),while RIF patients with PSYD-DAS without traditional Chinese medicine treatment were recruited as the control group(41 cases).Patients in the treatment group received WYHZC from 1-3 months before FET to 14 days after transplantation,while those the control group did not receive any intervention.All patients underwent FET within 3-6 months after the last transplantation failure.The general data of endometrial receptivity during FET and pregnancy outcomes within 12 weeks after transplantation were compared between the two groups.Results Five patients had natural pregnancy in the treatment group during the period of taking traditional Chinese medicine.There were significant differences in clinical pregnancy rate,sustained pregnancy rate,and endometrial thickness between the two groups(P<0.05).There were no significant differences in early abortion rate,endometrial morphology,or endometrial blood flow between the two groups(P>0.05).Conclusion WYHZC improved the endometrial thickness of RIF patients,and elevated the clinical pregnancy rate and the continuous pregnancy rate.
作者
胡祖贤
张玙
宋佳怡
夏天
HU Zu-xian;ZHANG Yu;SONG Jia-yi;XIA Tian(Reproduction Center,First Teaching Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin,300381)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2020年第9期1038-1041,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
天津市教委自然科学一般项目(No.2019KJ047)。
关键词
温阳化浊方
反复种植失败
子宫内膜容受性
冻融胚胎移植
妊娠结局
Wenyang Huazhuo Compound
repeated implantation failure
endometrial receptivity
frozen-thawed embryo transfer
pregnancy outcome
