摘要
目的本研究旨在研究不同比例钛纤维丝与自体微小颗粒骨早期复合修复兔桡骨缺损的能力,从而确定该复合材料的最佳比例。方法选取新西兰大耳白兔共计28只,入组兔均手术制作双侧桡骨缺损模型,将其平均分为四组,各7只。对照组为单纯骨缺损未修复;A组、B组、C组植入自体微小颗粒骨与I型胶原蛋白均匀混合复合物,同时A组植入1%含量钛纤维丝,B组植入5%含量钛纤维丝,C组植入9%含量钛纤维丝。术后6周进行大体形态学观察、X射线检查、电镜观察及力学测试。结果对照组骨骼缺损未能修复,A、B、C组组织学均得到修复,以C组最优。X线评分C组最优。电镜观察A、B、C组均有不同程度骨质沉积于钛纤维丝上,以C组最为显著。力学实验,C组受力最强。结论钛纤维丝与自体微小颗粒骨在早期复合修复兔桡骨缺损中效果较好,9%钛纤维丝与I型胶原蛋白均匀混合复合物为复合材料的最佳比例。
Objective To study the ability of different ratios of titanium fiber filaments and autologous micro-granular bone to repair rabbit radius defects early.Methods Selected 28 New Zealand rabbits.The rabbits in the group were all operated to make bilateral radius defect models,divided into four groups with 7 each.The control group was a simple bone defect without repair;groups A,B,and C were implanted with a homogeneous mixture of autologous micro-particle bone and type I collagen,while group A was implanted with 1%titanium fiber filament,and group B was implanted with 5%Content of titanium fiber thread,group C implanted 9%content of titanium fiber thread.Gross morphology observation,X-ray examination,electron microscope observation and mechanical test were performed 6 weeks after operation.Results The skeletal defect in the control group could not be repaired,and the histology of the A,B,and C groups was repaired.The C group was the best.The X-ray score was the best in group C.Electron microscopy observation showed that the bones of groups A,B,and C all had different degrees of deposition on titanium fiber filaments,with group C being the most significant.In mechanical experiments,group C was the most stressed.Conclusion Titanium fiber filaments and autogenous micro-granular bone are effective in early composite repair of rabbit radial defects.
作者
李宝权
李晓光
张志长
舒海
赵忠福
邹德勋
LI Baoquan;LI Xiaoguang;ZHANG Zhichang;SHU Hai;ZHAO Zhongfu;ZOU Dexun(Department of Orthopaedics,The Second Affiliated Hospital of Qiqihar Medical College,Qiqihar Heilongjiang 161000,China)
出处
《中国卫生标准管理》
2020年第17期57-60,共4页
China Health Standard Management
基金
齐齐哈尔市科学技术计划项目(SFGG-201722)。
关键词
钛纤维丝
自体小颗粒
骨缺损
骨质沉积
电镜观察
力学测试
titanium fiber filaments
autogenous small particles
bone defects
bone deposits
electron microscope observation
mechanical testing
