摘要
目的探讨原发性肝癌早期诊断中糖链抗原199(CA199)、癌胚抗原(CEA)、糖链抗原125(CA125)及甲胎蛋白(AFP)检验的准确性分析。方法选取2016年5月至2019年10月间上海中医药大学附属第七人民医院收治的126例原发性肝癌患者作为原发性肝癌组,选取同期50例良性肝病患者作为良性肝病组,选取同期接受健康体检的50例健康人员作为健康对照组。检测三组人员AFP、CEA、CA125和CA199水平,分析四者联合检测在原发性肝癌早期诊断中的应用效果。结果原发性肝癌组患者血清CA199、CEA、CA125及AFP水平均高于健康对照组和良性肝病组,差异均有统计学意义(均P <0.05);良性肝病组患者血清CA199、CEA、CA125和AFP水平高于健康对照组,差异均有统计学意义(均P <0.05)。原发性肝癌TNM分期Ⅲ~Ⅳ期患者血清CA199、CEA、CA125和AFP水平高于Ⅰ~Ⅱ期患者,差异均有统计学意义(均P <0.05)。原发性肝癌组患者CA199、CEA、CA125和AFP阳性率均高于健康对照组和良性肝病组,差异均有统计学意义(均P <0.05);良性肝病组患者CA199、CEA、CA125和AFP阳性率高于健康对照组,差异均有统计学意义(均P <0.05)。四者联合检测敏感度和准确度均高于各指标独立检测,差异均有统计学意义(均P <0.05)。结论原发性肝癌患者采用CA199、CEA、CA125及AFP指标进行检测,可有效评估早期原发性肝癌进展情况,且联合检测准确度更高,可有效降低漏诊率,值得在临床中进一步推广应用。
Objective To investigate the accuracy of carbohydrate antigen199( CA199),carcinoembryonic antigen( CEA),CA125 and α-fetoprotein( AFP) detection for early diagnosis of primary liver cancer. Methods From May 2016 to October 2019,126 patients with primary liver cancer treated at The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected as the primary liver cancer group,and 50 patients with benign liver disease treated in our hospital were selected as the benign liver disease group during the same period. Fifty healthy individuals receiving physical examination were included in a healthy control group. AFP,CEA,CA125,and CA199 levels of all the enrolled participants were tested to analyze the effect of the combined detection for early diagnosis of primary liver cancer. Results The levels of CA199,CEA,CA125 and AFP in the serum were significantly higher in the primary liver cancer group than in the control group and the benign liver disease group( all P <0. 05). The levels of the above markers were significantly higher in the benign liver disease group than the control group( all P < 0. 05). The levels of the above markers were significantly higher in patients with TNM stage III to IV primary liver cancer than those with stage I to II primary liver cancer( all P < 0. 05).The positive rates of CA125,CA125 and AFP were significantly higher in primary liver cancer group than the control group and benign liver disease group( all P < 0. 05). The positive rates of CA199,CEA,CA125 and AFP were significantly higher in the benign liver disease group than in the control group( all P < 0. 05). The sensibility and accuracy of combined detection is significantly higher than the independent detection of CA199,CEA,CA125,and AFP indicators,respectively( all P < 0. 05). Conclusion The detection of CA199,CEA,CA125 and AFP can effectively assess the progress of early primary liver cancer disease,and the accuracy of the combined detection is high,which can effectively reduce the rate of missed diagnosis and can be further promoted in clinical applications.
作者
张杨
项舟弘
段爱华
ZHANG Yang;XIANG Zhou-hong;DUAN Ai-hua(Department of Medical Laboratory,The Seventh Peopled Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)
出处
《中国肿瘤临床与康复》
2020年第8期969-972,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
