摘要
本文报告１０例肛管直肠恶性黑色素瘤的临床病理及免疫组织化学特点。１０例病人男女之比为２．３∶１，平均平龄５７．１岁，主要症状为便血、肛门肿物。４例发生于肛管部，４例发生于齿状线，２例于直肠下端。肉眼见呈结节状，息肉状或溃疡型。镜下形态多样，主要为上皮细胞，梭形细胞等，８例见黑色素颗粒。肿瘤细胞对Ｓ－１００及ＨＭＢ－４５抗体呈阳性反应。对该病的组织发生、形态学及病理诊断进行了讨论。
Theclinicopatholigicalandimmunohistochemicalfeaturesofanorectalmalignantmelanomain10caseswerereported.Thesexratioofmaleandfemalewas2.3:1,themeanagewas57.1years.Themainpresentingsymptomswerebloodystoolandapalpablemassintheanus.Thetumorwaslocatedintheanalcanalinfourcases,atthedentateliveinan-otherfourcasesandatthelowerendoftherectumintwo.Grossly,thetumoroftenshowednodular,polypoidorulceratedshape.Histologicaly,therewerevariousforms,suchasepithelialorspindlecels.Pregmentgranuleswereseenin8cases.Im-munohistochemicalstudiesshowedthattheneoplasticcelsreactedpositivelytoanti-S-100proteinandanti-HMB-45antibod-ies.Inthispaper,thepathogensis,morphologyandpathologicaldignosisofanorectalmalignantmelanomawerediscussed.
