摘要
目的系统评价孕妇在正常机体代谢情况下妊娠期血清硒水平与早产的相关性。方法计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、CNKI和CBM数据库,收集孕妇血清硒水平与早产相关性的病例-对照研究或队列研究,检索时限均从建库至2020年1月。由2名评价员独立筛选文献、提取资料和评价纳入文献的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入12个研究2 484例患者。Meta分析结果显示:与足月组相比,早产组孕妇妊娠期血清硒水平更低[SMD=-0.89,95%CI(-1.56,-0.22),P=0.01]。按研究国家所属洲际、孕妇血样采集时间和检测方法等进行亚组分析,组间异质性仍较大。结论孕妇妊娠期血清硒水平低可能是早产的风险因素之一;但受纳入研究数量与质量的限制,上述结论仍需开展更多高质量研究予以验证。
Objectives To systematically review the correlation between maternal serum selenium levels during pregnancy and premature birth. Methods Databases including PubMed, The Cochrane Library, EMbase, Web of Science, CNKI and CBM were searched to collect studies on correlation between maternal serum selenium levels during pregnancy with preterm birth in the offspring from inception to January, 2020. Two reviewers independently screened literature, extracted data and evaluated risk of bias of the included literature. Then, meta-analysis was conducted by using RevMan 5.3 software. Results A total of 12 studies involving 2 484 patients were included. The results of meta-analysis showed that compared with control group, the preterm group had lower serum selenium levels in pregnant females(SMD=-0.89, 95%CI-1.56 to-0.22, P=0.01). The results of the subgroup analysis showed that heterogeneity among subjects was still large when grouped accorcding to the continent to which a country belongs, the time of blood sample collection and test method in pregnant females. Conclusions Low maternal serum selenium levels during pregnancy may increase the risk of preterm birth. Due to the limitation of the quantity and quality of the included studies, the above conclusions are required to be verified by more high quality studies.
作者
刘璐
魏莉莉
刘东海
王佳斌
王燕侠
毛宝宏
虎亚光
仇杰
杨克虎
LIU Lu;WEI Lili;LIU Donghai;WANG Jiabin;WANG Yanxia;MAO Baohong;HU Yaguang;QIU Jie;YANG Kehu(Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,P.R.China;Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,P.R.China;Evidence-based Medicine Center of Lanzhou University,Lanzhou 730000,P.R.China;Key Laboratory of Evidence-Based Medicine and Clinical Transformation in Gansu Province,Lanzhou 730000,P.R.China;School of Public Health,Lanzhou University,Lanzhou 730000,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2020年第9期1045-1051,共7页
Chinese Journal of Evidence-based Medicine
基金
兰州大学中央高校基本科研业务费专项资金资助(项目编号:2019jbkyzy002,lzujbky-2019-ct02,2020jbkyzx001,lzujbky-2020-kb20)。
