摘要
目的观察仁冬汤对房颤患者的临床疗效及心房结构重构、血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法非瓣膜性房颤患者112例采用随机数字表法分为对照组及治疗组各56例,对照组给予达比加群酯胶囊及琥珀酸美托洛尔缓释片治疗,治疗组在对照组基础上给予仁冬汤治疗。比较两组治疗前及治疗4周后心房结构与功能指标、血清CRP、IL-6、TNF-α水平及临床疗效情况。结果治疗前,两组左室舒张末期内径(LVEDD)、左房内径(LAD)、左室收缩末期容积(LVESV)、右房内径(RAD)等心房结构指标,左心房主动脉射血分数(LAAEF)、二尖瓣脉冲E波速度峰值(VE)、A波峰值(VA)、VE/VA等心房功能指标,血清CRP、IL-6、TNF-α等比较差异无统计学意义(P>0.05);治疗后,两组LVEDD、LAD、RAD、LVESV、VE/VA、LAAEF、VA、VE比较差异无统计学意义(P>0.05);治疗组治疗4周后CRP、IL-6、TNF-α均低于对照组;治疗组临床总有效率为91.07%,明显高于对照组的75.00%(P<0.05);两组治疗后中医证候积分均改善,治疗组改善更明显(P>0.05)。结论仁冬汤治疗房颤临床疗效确切,能明显降低房颤患者血清中炎性因子表达,但在改善房颤患者心房结构重构方面没有得出阳性结果。
Objective:To explore the effect of Rendong Decoction on atrial remodeling,serum CRP,IL-6,TNF-αand other inflammatory factors in patients with atrial fibrillation.Methods:112 patients were randomly divided into the control group and the treatment group,56 cases in each.The control group were treated with Dabigatran capsule and metoprolol succinate sustained-release tablets.The treatment group were treated with Rendong Decoc⁃tion on that basis.The changes of atrial structure and function,serum CRP,IL-6,TNF-αand other inflammatory factors and clinical efficiency were compared between the two groups before and after treatment.Results:Before treatment,there were no significant differences in LVEDD,LAD,RAD,LVESV,LAAEF,VE,VA,VE/VA,CRP,IL-6 and TNF-αbetween the two groups(P>0.05);after treatment,there were no significant differences in LVEDD,LAD,RAD,LVESV,LAAEF,VE,VA and VE/VA between the two groups(P>0.05);CRP,IL-6 and TNF-αin the treatment group were lower than those in the control group(P<0.05).The total effective rate was 91.07%in the treatment group,significantly higher than that in the control group(75.00%)(P<0.05).The TCM scores in 2 groups were both improved.The improvements in the treatment group were more obvious(P<0.05).Conclusion:Rendong Decoction has a definite clinical effect on atrial fibrillation,which can significantly reduce the expression of inflammatory factors in the serum of patients with atrial fibrillation,but there are no positive results in the im⁃provement of atrial structural remodeling in patients with atrial fibrillation.
作者
孙龙飞
徐风燕
安冬青
Sun Longfei;Xu Fengyan;An Dongqing(Affiliated Hospital of Traditional Chinese Med-icine,Xinjiang Medical University,Xinjiang,Urumqi 830000,China)
出处
《中国中医急症》
2020年第9期1618-1621,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
新疆医科大学附属中医医院课题(ZYYZ201701)。
关键词
心房颤动
心房结构重构
仁冬汤
炎性因子
Atrial fibrillation
Atrial relocation
Rendong Decoction
Inflammatory factors
