摘要
目的研究没药属没药Commiphora myrrha的倍半萜类化学成分。方法采用硅胶、Sephadex LH-20、ODS等多种柱色谱,结合制备液相等方法进行分离和纯化,根据理化性质及波谱数据对化学成分进行结构鉴定。结果从没药二氯甲烷提取物中分离得到10个倍半萜类化合物,分别鉴定为11-methoxyl-guaia-6,10-dien-4α-ol(1)、(1R,4S,5R,10R)-isodauc-6-en-10,14-diol(2)、 10α-hydroxy-isodauc-6-en-14-al(3)、 guaia-6,10-dien-4α,11-diol(4)、 orientalolB(5)、(1S,4R,5R,10S)-isodauc-6-en-10,14-diol (6)、(1S,4S,5R,10S)-isodauc-6-en-10,14-diol (7)、alismanoid C (8)、guaiandiol (9)、canangaterpene Ⅵ (10)。结论化合物1为新化合物,命名为没药醇A。化合物2~10均为首次从该属植物中分离得到。
Objective To study the chemical constituents from Myrrha. Methods The compounds were isolated and purified by column chromatography over silica gel, Sephadex LH-20, RP-ODS and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results Ten sesquiterpenes were isolated and identified as 11-methoxylguaia-6,10-dien-4α-ol(1),(1 R,4 S,5 R,10 R)-isodauc-6-en-10,14-diol(2), 10α-hydroxy-isodauc-6-en-14-al(3), guaia-6,10-dien-4α,11-diol(4), orientalol B(5),(1 S,4 R,5 R,10 S)-isodauc-6-en-10,14-diol(6),(1 S,4 S,5 R,10 S)-isodauc-6-en-10,14-diol(7), alismanoid C(8), guaiandiol(9) and canangaterpene Ⅵ(10). Conclusion Compound 1 is a new compound, named as commiphorol A and compounds 2—10 are isolated from the genus for the first time.
作者
刘冠科
李思瑶
丁丽琴
王莉宁
邱峰
LIU Guan-ke;LI Si-yao;DING Li-qin;WANG Li-ning;QIU Feng(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第13期3372-3377,共6页
Chinese Traditional and Herbal Drugs
基金
国家重点研发计划资助(2019YFC1711000)
西青区鼓励高端制造创新驱动发展项目(cgzh-cgk-201801)。
