摘要
巨噬细胞是固有免疫的重要成员,在机体防御病原生物感染、肿瘤、过敏性疾病等发生发展中发挥着极其重要的作用。巨噬细胞具有高度可塑性,在不同环境刺激下巨噬细胞可极化为经典活化型巨噬细胞(M1型巨噬细胞)和替代活化型巨噬细胞(M2型巨噬细胞)。M1型巨噬细胞能够促进机体炎症反应,有利于清除病原体;M2型巨噬细胞能够抑制炎症反应,有利于病原体生存、繁殖。本文综述巨噬细胞极化在寄生虫感染中的作用,为寄生虫病防治研究提供参考。
Macrophages are important members of innate immunity and play an extremely important role in the host defense against pathogenic infections,tumors,and allergic diseases.Macrophages have a high degree of plasticity,and may be polarized into classical activated macrophages(M1 macrophages) and alternative activated macrophages(M2 macrophages) under the stimulation of different environments.M1 macrophages are found to promote inflammatory responses,which facilitates the clearance of pathogens,while M2 macrophages may inhibit inflammatory responses,which facilitates the survival and reproduction of pathogens.This review summarizes the role of macrophage polarization in parasitic infections,so as to provide insights into the prevention and treatment of parasitic diseases.
作者
蔡娟
黄琳
王灵军
郑明辉
刘晖
CAI Juan;HUANG Lin;WANG Ling-Jun;ZHENG Ming-Hui;LIU Hui(Department of Parasitology,Zunyi Medical College,Zunyi 563000,China;Guizhou Key Laboratory of Gene Detection and Treatment,Zunyi Medical College,China;Qiannan Medical College for Nationalities,China)
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2020年第4期432-435,共4页
Chinese Journal of Schistosomiasis Control
基金
国家自然科学基金地区基金(81560336、81760373)
贵州省科技厅科技基金(黔科合基础[2016]1168)
黔南民族医学高等专科学校科研基金资助项目(QNYZ201928)。
关键词
巨噬细胞极化
寄生虫
免疫反应
Macrophage polarization
Parasite
Immune response
