摘要
目的探讨来曲唑改善体外受精-胚胎移植中卵巢慢反应患者的临床效果及机制。方法选取2016年7月至2017年2月收治的使用常规长方案进行IVF/ICSI采卵周期并出现卵巢慢反应的患者40例,根据临床治疗方案不同将其分为来曲唑组和rLH组,每组20例。比较2组患者Gn用药数、用药时间、促排卵治疗反应情况、妊娠情况、血与卵泡液中雄烯二酮、睾酮、孕激素、雌二醇水平。结果来曲唑组Gn用药数、用药时间短于rLH组,差异有统计学意义(P<0.05),促排卵治疗效果高于rLH组,差异有统计学意义(P<0.05);来曲唑组周期取消率、着床率高于rLH组,差异有统计学意义(P<0.05),获卵数多于rLH组,差异有统计学意义(P<0.05);来曲唑组继续妊娠、临床妊娠、妊娠率高于rLH组,差异有统计学意义(P<0.05);来曲唑组雄烯二酮、睾酮、孕激素水平高于rLH组,差异有统计学意义(P<0.05),雌二醇水平低于rLH组,差异有统计学意义(P<0.05)。结论体外受精-胚胎移植中卵巢慢反应患者治疗中,来曲挫的效果显著,值得应用。
Objective To investigate the clinical effects and action mechanism of letrozole in improving ovarian slow reaction in vitro fertilization embryo transfer.Methods A total of 40 patients who were admitted and treated in our hospital from July 2016 to February 2017 were enrolled in the study,who underwent IVF/ICSI egg collection cycle and appeared ovarian slow response,who were divided into the letrozole group(n=20)and rLH group(n=20)according to the different clinical therapeutic schedules.The pharmacy dose of Gn,the medication time,the response to ovulation induction,the pregnancy status,and the levels of androstenedione,testosterone,progesterone,and estradiol in blood and follicular fluid were observed and compared between the two groups.Results The medication dose and medication time in letrozole group were significantly less than those in rLH group(P<0.05).However the effects of ovulation induction in letrozole group were significantly better than those in rLH group(P<0.05).Moreover the cycle cancellation rate and implantation rate in letrozole group were significantly higher than those in rLH group(P<0.05).The number of eggs obtained in letrozole group was significantly higher than that in rLH group(P<0.05).In addition,the continued pregnancy,clinical pregnancy,pregnancy rate in letrozole group were significantly higher than those in rLH group(P<0.05).Moreover the levels of androstenedione,testosterone and progesterone in letrozole group were significantly higher than those in rLH group(P<0.05),but,the estradiol levels in letrozole group were significantly lower than those in rLH group(P<0.05).Conclusion In the treatment of patients with ovarian slow response in vitro fertilization embryo transfer,the curative effects of the letrozole are significant,thus,which is worthy of application and promotion in clinical practice.
作者
杨素娟
许月明
张杰
姚朝辉
王会霞
王少卿
郝桂敏
YANG Sujuan;XU Yueming;ZHANG Jie(The Second Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China)
出处
《河北医药》
CAS
2020年第19期2954-2956,2960,共4页
Hebei Medical Journal
基金
河北省医学科学研究重点计划(编号:20170070)。
关键词
来曲挫
体外受精-胚胎移植
卵巢慢反应
效果
机制
letrozole
in vitro fertilization embryo transfer
ovarian slow reaction
effects
mechanism
