摘要
目的探讨乳头状肾细胞癌(PRCC)的临床病理特征,并对预后的相关因素进行分析。方法回顾性分析70例PRCC患者的临床病理资料,并对患者生存及复发转移情况进行跟踪随访。结果 70例PRCC患者中Ⅰ型37例,Ⅱ型33例;Furhman分级1~2级47例,3~4级23例;肿瘤直径<4 cm者41例,4~7 cm者16例,>7 cm者13例;T1~T2期57例,T3~T4期13例;发生淋巴结转移者10例,脉管内查见癌栓者11例,随访过程中发生远处转移者9例,死亡1例。影响患者预后的因素为TNM分期、Fuhrman分级以及肿瘤直径,即pTNM分期及Fuhrman分级越高,肿瘤直径越大,伴有癌栓则患者的预后越差。结论 PRCC恶性度较低,患者整体预后较好,但不同亚型预后不同,Ⅱ型更容易发生脉管内癌栓、淋巴结及远处转移;并且在形态上PRCC要与多种肾肿瘤进行鉴别。
Objective To investigate the clinicopathological features of papillary renal cell carcinoma(PRCC) and to analyze the prognostic factors.Methods The clinicopathological data of 70 cases of PRCC were analyzed retrospectively,the survival and metastasis of the patients were followed up.Results Among the 70 PRCC patients,37 cases were type Ⅰ,33 cases were type Ⅱ.47 cases were Furhman grade 1-2,23 cases were grade 3-4.The tumor size was < 4 cm in 41 cases,16 cases were ranged from 4 to 7 cm,13 cases were >7 cm.57 cases were T1-T2 and 13 cases were T3-T4.Lymph node metastasis were identified in 10 cases,11 cases presented tumor embolism,and 9 cases had metastatic disease and 1 died of disease during follow-up.The factors that affected the prognosis of patients were TNM stage,Fuhrman grade and tumor diameter.The higher the pTNM stage and Fuhrman grade,the larger the tumor diameter,and the worse the prognosis of patients with tumor embolism.Conclusion The prognosis of patients with PRCC is better,but the prognosis of different subtypes is different.Type Ⅱ is more likely to have tumor embolism,lymph node and distant metastasis.Morphologically,PRCC should be differentiated from a variety of renal tumors.
作者
葛冲
吴海波
GE Chong;WU Hai-bo(Department of Pathology,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230036,China)
出处
《诊断病理学杂志》
2020年第8期543-547,共5页
Chinese Journal of Diagnostic Pathology
基金
安徽省自然科学基金(1908085MH281)
中央高校基本科研业务费专项资金(WK9110000042)。
关键词
乳头状肾细胞癌
预后
鉴别诊断
Papillary renal cell carcinoma
Prognosis
Differential disgnosis
