摘要
目的探究枳术理中汤联合化疗对晚期胃肠道恶性肿瘤患者的疗效研究。方法选取2018年1—12月于本院接受治疗的102例晚期胃肠道恶性肿瘤患者为受试对象,随机数字表法分为观察组与对照组,各51例。对照组予以FOLFOX化疗,观察组在其基础上服用枳术理中汤进行治疗。比较两组临床疗效及治疗前、治疗6个月后免疫功能变化情况,并记录毒副反应发生情况。结果治疗6个月后,观察组总有效率为51.0%,显著高于对照组的31.4%(P <0.05);治疗前,两组患者各项免疫指标比较差异无统计学意义(P> 0.05),治疗6个月后,观察组患者CD3+、CD4+、CD4+/CD8+水平均明显高于同期对照组(P<0.05),而CD8+水平明显低于对照组(P <0.05);两组患者肝功能异常、肾功能异常发生率比较差异无统计学意义(P> 0.05),而观察组恶心呕吐、腹泻及白细胞减少发生率低于对照组(P <0.05)。结论枳术理中汤确可明显减少胃肠道恶性肿瘤患者化疗后胃肠道反应,还可提升患者免疫功能,对患者治疗效果有利。
Objective To explore the efficacy of zhizhu lizhong decoction combined with chemotherapy on patients with advanced gastrointestinal malignant tumor.Methods A total of 102 patients with advanced gastrointestinal malignant tumor who were treated in our hospital from January to December 2018 were selected as subjects,and they were divided into observation group and control group according to the random number table method,with 51 cases in each group.Control group was given FOLFOX chemotherapy,and observation group was treated with zhizhu lizhong decoction on this basis.The clinical efficacy and changes of immune function before treatment and after 6 months of treatment were compared between the two groups,and the occurrence of toxic and side effects were recorded.Results After 6 months of treatment,the total effective rate in observation group was significantly higher than that in control group(51.0%vs.31.4%)(P<0.05).Before treatment,there were no statistically significant differences in the immune parameters between the two groups(P>0.05).After 6 months of treatment,the levels of CD3+,CD4+and CD4+/CD8+in observation group were significantly higher than those in control group during the same period(P<0.05),while the level of CD8+was significantly lower than that in control group(P<0.05).There were no statistically significant differences in the incidence rates of liver dysfunction and renal dysfunction between the two groups(P>0.05),but the incidence rates of nausea and vomiting,diarrhea and leukopenia in observation group were lower than those in control group(P<0.05).Conclusion lizhong decoction Decoction can obviously reduce the gastrointestinal response of patients with gastrointestinal malignant tumor after chemotherapy,and can also improve the immune function of patients,and it is beneficial for treatment ef fects of patients.
作者
林麟
章浩军
LIN Lin;ZHANG Haojun(Department of Internal Medicine of Traditional Chinese Medicine,Longyan Hospital of Traditional Chinese Medicine,Longyan Fujian 364000,China)
出处
《中国卫生标准管理》
2020年第18期102-105,共4页
China Health Standard Management
基金
第六批全国名老中医药专家学术经验继承工作项目(2017125)。
关键词
枳术理中汤
恶性肿瘤
胃肠道反应
疗效
化疗
毒副反应
免疫功能
zhizhu lizhong decoction
malignant tumor
gastrointestinal response
efficacy
chemotherapy
toxic and side effects
immune function
