摘要
目的:观察健脾止泻汤联合鞣酸蛋白酵母散治疗小儿腹泻的临床疗效及对患儿免疫功能的影响。方法:将198例患儿随机分为两组,对照组(98例)采用鞣酸蛋白酵母散进行治疗,观察组(100例)在对照组治疗的基础上治以健脾止泻汤,两组均连续治疗6天。比较两组临床有效率、临床症状改善情况、免疫功能相关指标、不良反应及复发情况。结果:总有效率观察组为96.00%(96/100),对照组为85.71%(84/98),两组比较差异有统计学意义(P<0.05)。退热时间、腹痛缓解时间、排便恢复正常时间、呕吐缓解时间两组比较,差异有统计学意义(P<0.05)。CD4+/CD8+、免疫球蛋白A(immunoglobulin A,IgA)及免疫球蛋白G(immunoglobulin G,IgG)水平治疗前后两组组内比较,差异有统计学意义(P<0.05);治疗后两组组间比较差异也有统计学意义(P<0.05)。两组治疗期间均未出现明显不良反应;观察组患儿未见复发,对照组复发5例,复发率观察组显著低于对照组(χ^2=5.234,P=0.028)。结论:健脾止泻汤联合鞣酸蛋白酵母散可显著提高小儿腹泻治疗的临床有效性,缩短症状恢复时间,提高患儿免疫力并降低复发率。
Objective:To observe clinical effects of spleen-invigorating diarrhea-stopping decoction joined with albumin tannate and barm powder in treating infantile diarrhea,and its influence on immunologic function.Methods:A total of 198 children were randomized into two groups,the control group(98 cases)adopted albumin tannate and barm powder,and the observation group(100 cases)were treated by spleen-invigorating diarrhea-stopping decoction based on the therapy the control group accepted,both groups were treated for six days consecuti-vely.To compare clinical effective rate,the improvements of clinical symptoms,the related indexes of immunologic function,adverse reaction and the relapse conditions between both groups.Results:Total effective rate of the observation group was 96.00%(96/100),higher than 85.71%(84/98)of the control group,and the difference had statistical meaning(P<0.05).The difference had statistical meaning in the time of bringing down fever,relief time of abdominal pain,the time of defecation restoring to normal,relief time of vomiting between both groups(P<0.05).The difference was statistically significant in the levels of CD4+/CD8,IgA and IgG within two groups before and after treating(P<0.05);the difference had statistical meaning between both groups after treating(P<0.05).No obvious adverse reaction happened during therapeutic period in both groups;no relapse occured in the observation group,five cases relapsed in the control group,the relapse rate of the observation group was lower than that of the control group(χ^2=5.234,P=0.028).Conclusion:Spleen-invigorating diarrhea-stopping decoction joined with albumin tannate and barm powder in treating infantile diarrhea could notably raise clinical effectiveness,shorten the recovery time of symptoms,lift the immunity and reduce relapse rate.
作者
王文学
WANG Wenxue(Pediatric Department,Fufeng County TCM Hospital,Fufeng 722200,China)
出处
《西部中医药》
2020年第8期109-111,共3页
Western Journal of Traditional Chinese Medicine
关键词
腹泻
健脾止泻汤
鞣酸蛋白酵母散
临床疗效
免疫功能
小儿
diarrhea
spleen-invigorating diarrhea-stopping decoction
albumin tannate and barm powder
clinical effects
immunologic function
infants
