摘要
目的探讨肾穿刺造瘘术后肾盂尿液中肌酐、尿比重、尿pH值、β2-微球蛋白(β2-MG)、清蛋白(Alb)、免疫球蛋白(IgG)及T-H糖蛋白(THP)水平在肾功能恢复评价中的应用。方法回顾性分析2018年2月至2019年10月我院收治的46例先天性单侧重度肾积水患儿。另收集同期肾功能正常的体检儿童尿液30份为健康对照组。根据穿刺造瘘术后24 h内与术后12周患侧肾盂尿液中肌酐、尿比重、尿pH值、β2-MG、Alb、IgG及THP等指标评估肾功能变化。结果研究组术后24 h肾盂尿液中尿pH值、肌酐、β2-MG、IgG、Alb及THP水平均高于对照组,尿比重低于对照组,差异有统计学意义(P<0.05)。术后24 h及术后12周,肾切除组患儿肾盂尿液中各指标比较差异均无统计学意义(P>0.05)。术后24 h及术后12周肾保留组患儿肾盂尿液中尿pH值、肌酐、β2-MG、IgG、Alb及THP水平比较差异有统计学意义(P<0.05)。结论重度肾积水患儿行经皮肾穿刺引流术后肾功能可有不同程度的恢复,经检测证实,尿pH值、肌酐、β2-MG、IgG、Alb及THP水平有可能作为评价术后肾功能恢复的理想指标,可为下一步治疗方案提供依据。
Objective To investigate the application of creatinine(CR),specific gravity of urine,pH value of urine,β2-microglobulin(β2-MG),albumin(ALB),immunoglobulin(IgG)and T-H glycoprotein(THP)in the evaluation of renal function recovery after nephrostomy.Methods A retrospective analysis of 46 children with unilateral severe congenital hydronephrosis from February 2018 to October 2019 was conducted.The urine of 30 children with normal renal function in the same period was collected as the normal control group.The renal function was evaluated by Cr,specific gravity of urine,pH value of urine,β2-MG,ALB,IgG and THP in the urine of the affected side of renal pelvis within 24 hours and 12 weeks after the operation.Results The levels of urine pH,Cr,β2-MG,IgG,ALB and THP were higher in the study group than those in the control group,and the urine specific gravity was lower than that in the control group(P<0.05).At 24 hours and 12 weeks after the operation,there was no significant difference among the renal pelvis urine indexes in the nephrectomy group(P>0.05).The levels of urine pH,Cr,β2-MG,IgG,ALB and THP were of significant differences in the two groups(P<0.05).Conclusion The renal function of children with severe hydronephrosis can be restored to different degrees after percutaneous renal puncture and drainage.It is confirmed by detection that urine pH value,Cr,β2-MG,IgG,ALB and THP levels may be ideal indicators for evaluating the recovery of renal function after operation,and may provide basis for the next treatment plan.
作者
张争春
王录文
何士军
马龙
闵晓明
李涛
Zhang Zhengchun;Wang Luwen;He Shijun;Ma Long;Kan Xiaoming;Li Tao(Department of Urology,Xi′an First Hospital,Shaanxi 710001,China)
出处
《山西医药杂志》
CAS
2020年第18期2437-2440,共4页
Shanxi Medical Journal
关键词
肾造口术
经皮
Β2-微球蛋白
肾积水
肾功能
Nephrostomy,percutaneous
Beta 2 microglobulin
Hydronephrosis
Renal function
